All Phenotypes Hprt1<tm1(Ins2-HBEGF)Herr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hprt1^{tm1(Ins2-HBEGF)Herr}/Hprt1^{tm1(Ins2-HBEGF)Herr}	involves: 129 * C57BL/6	MGI:5567826
cn2	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Hprt1^{tm1(Ins2-HBEGF)Herr}/Y Tg(Gcg-rtTA)#Herr/0 Tg(tetO-cre)1Jaw/0	involves: 129X1/SvJ * C57BL/6	MGI:5567830
cn3	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Hprt1^{tm1(Ins2-HBEGF)Herr}/Y Tg(Ins2-cre/ERT)1Dam/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:5567828
cx4	Hprt1^{tm1(Ins2-HBEGF)Herr}/Y Tg(Gcg-HBEGF)#Herr/0	involves: 129 * C57BL/6	MGI:5567829
ot5	Hprt1^{tm1(Ins2-HBEGF)Herr}/Y	involves: 129 * C57BL/6	MGI:5567827

Allelic Composition	Hprt1^{tm1(Ins2-HBEGF)Herr}/Hprt1^{tm1(Ins2-HBEGF)Herr}
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(Ins2-HBEGF)Herr} mutation (0 available); any Hprt1 mutation (1274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:159291 )

• in diphtheria-treated mice

Allelic Composition	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Hprt1^{tm1(Ins2-HBEGF)Herr}/Y Tg(Gcg-rtTA)#Herr/0 Tg(tetO-cre)1Jaw/0
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (944 available)
Hprt1^{tm1(Ins2-HBEGF)Herr} mutation (0 available); any Hprt1 mutation (1274 available)
Tg(Gcg-rtTA)#Herr mutation (0 available)
Tg(tetO-cre)1Jaw mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic alpha cell differentiation ( J:159291 )

• alpha cells in diphtheria-treated mice transdifferentiate into beta cells

cellular

abnormal pancreatic alpha cell differentiation ( J:159291 )

• alpha cells in diphtheria-treated mice transdifferentiate into beta cells

Allelic Composition	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Hprt1^{tm1(Ins2-HBEGF)Herr}/Y Tg(Ins2-cre/ERT)1Dam/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:159291 )

N	• spared beta cells in diphtheria- and tamoxifen-treated mice do not exhibit increased replication

abnormal pancreatic islet morphology ( J:159291 )

• bihormonal (glucagon+ and insulin+) cells arise in the islets of diphtheria-treated mice

Allelic Composition	Hprt1^{tm1(Ins2-HBEGF)Herr}/Y Tg(Gcg-HBEGF)#Herr/0
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(Ins2-HBEGF)Herr} mutation (0 available); any Hprt1 mutation (1274 available)
Tg(Gcg-HBEGF)#Herr mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:159291 )

N	• following diphtheria depletion of beta cells, mice fail to develop bihormonal cells observed in similarly treated mice with alpha cells intact

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:159291 )

• in diphtheria-treated mice

• however, treatment with insulin rescues premature death

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:159291 )

• mild fibrosis in diphtheria-treated mice

• bihormonal (glucagon+ and insulin+) cells arise in the islets of diphtheria-treated mice

decreased pancreatic beta cell mass ( J:159291 )

• in diphtheria-treated mice

increased pancreatic beta cell mass ( J:159291 )

• between 15 days and 1 month after diphtheria treatment

decreased pancreatic beta cell number ( J:159291 )

• in diphtheria-treated mice

abnormal pancreatic beta cell physiology ( J:159291 )

• apoptotic in diphtheria-treated mice

• beta cell regeneration 15 days to 1 month after diphtheria treatment

• however, treated mice do not exhibit inflammation, insulitis or extra-insular cell death

decreased insulin secretion ( J:159291 )

• in the pancreas of diphtheria-treated mice

increased insulin secretion ( J:159291 )

• in the pancreas between 15 days and 1 month after diphtheria treatment

homeostasis/metabolism

decreased insulin secretion ( J:159291 )

• in the pancreas of diphtheria-treated mice

increased insulin secretion ( J:159291 )

• in the pancreas between 15 days and 1 month after diphtheria treatment

hyperglycemia ( J:159291 )

• in diphtheria-treated mice

ketoacidosis ( J:159291 )

• ketoacidosis in diphtheria-treated mice

behavior/neurological

polydipsia ( J:159291 )

• in diphtheria-treated mice

growth/size/body

weight loss ( J:159291 )

• in diphtheria-treated mice

renal/urinary system

polyuria ( J:159291 )

• in diphtheria-treated mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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