About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc39a5tm1Gka
targeted mutation 1, Glen K Andrews
MGI:5566985
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Slc39a5tm1Gka/Slc39a5tm1Gka
Tg(Cela1-cre/ERT)1Lgdn/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:5581459
cn2
 		Slc39a5tm1Gka/Slc39a5tm1Gka
Tg(Vil1-cre/ERT2)23Syr/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5581458


Genotype
MGI:5581459
cn1
Allelic
Composition		 Slc39a5tm1Gka/Slc39a5tm1Gka
Tg(Cela1-cre/ERT)1Lgdn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc39a5tm1Gka mutation (1 available); any Slc39a5 mutation (28 available)
Tg(Cela1-cre/ERT)1Lgdn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Slc39a5tm1Gka/Slc39a5tm1Gka Tg(Cela1-cre/ERT)1Lgdn/0 mice exhibit increased sensitivity to zinc-induced acute pancreatitis

homeostasis/metabolism
decreased liver iron level ( J:209760 )
• in tamoxifen-treated mice
abnormal zinc homeostasis ( J:209760 )
• tamoxifen-treated mice exhibit increased susceptibility to zinc-induced pancreatitis compared with control mice
• tamoxifen-treated mice fed excess zinc exhibit reduced pancreatic accumulation due to reduced zinc retention compared with control mice
• however, mice exhibit normal pancreatic zinc uptake

endocrine/exocrine glands
pancreatic acinar cell atrophy ( J:209760 )
• in tamoxifen-treated mice exposed to zinc
increased susceptibility to induced pancreatitis ( J:209760 )
• tamoxifen-treated mice exhibit increased susceptibility to zinc-induced pancreatitis compared with control mice

liver/biliary system
decreased liver iron level ( J:209760 )
• in tamoxifen-treated mice

immune system
increased susceptibility to induced pancreatitis ( J:209760 )
• tamoxifen-treated mice exhibit increased susceptibility to zinc-induced pancreatitis compared with control mice

digestive/alimentary system
pancreatic acinar cell atrophy ( J:209760 )
• in tamoxifen-treated mice exposed to zinc




Genotype
MGI:5581458
cn2
Allelic
Composition		 Slc39a5tm1Gka/Slc39a5tm1Gka
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc39a5tm1Gka mutation (1 available); any Slc39a5 mutation (28 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal zinc homeostasis ( J:209760 )
• tamoxifen-treated mice provided adequate or excess zinc (by diet or gavage) exhibit increased pancreatic zinc compared with control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory