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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gcgrtm2.1Mjch
targeted mutation 2.1, M J Charron
MGI:5566811
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gcgrtm2.1Mjch/Gcgrtm2.1Mjch
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * DBA * SJL MGI:5566824


Genotype
MGI:5566824
cn1
Allelic
Composition
Gcgrtm2.1Mjch/Gcgrtm2.1Mjch
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background
involves: C57BL/6 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcgrtm2.1Mjch mutation (0 available); any Gcgr mutation (5 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increased alpha-cell proliferation

homeostasis/metabolism
• abrogated hyperglycemic response to acute glucagon challenge
• in fasted and random samples
• mild
• of total levels in plasma

endocrine/exocrine glands
• increased alpha-cell proliferation
• alpha-cell hyperplasia
• increased beta-cell mass is secondary to enlargement of the pancreas

growth/size/body





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory