All Phenotypes Stag3<tm1e.1(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Stag3^{tm1e.1(KOMP)Wtsi}
targeted mutation 1e.1, Wellcome Trust Sanger Institute
MGI:5565201

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}	B6N(Cg)-Stag3^{tm1e.1(KOMP)Wtsi}	MGI:6506382
hm2	Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}	C57BL/6N-Stag3^{tm1e.1(KOMP)Wtsi}/J	MGI:5757773
cx3	Prdm9^tm1Ymat/Prdm9^tm1Ymat Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}	B6.Cg-Prdm9^tm1Ymat Stag3^{tm1e.1(KOMP)Wtsi}	MGI:6506415
cx4	Spo11^tm1Mjn/Spo11⁺ Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}	B6.Cg-Spo11^tm1Mjn Stag3^{tm1e.1(KOMP)Wtsi}/2J	MGI:6506426
cx5	Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}	B6N(Cg)-Rad21l^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}	MGI:6506392
cx6	Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}	B6N(Cg)-Rec8^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}	MGI:6506390
cx7	Prdm9^em3Kpgn/Prdm9^em3Kpgn Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}	involves: C57BL/6J * C57BL/6N	MGI:6506422

Allelic Composition	Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
Genetic Background	B6N(Cg)-Stag3^{tm1e.1(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stag3^{tm1e.1(KOMP)Wtsi} mutation (1 available); any Stag3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal chromosomal synapsis ( J:280261 )

• aberrant homolog pairing with increased incidence of chromosomes occupying more than one territoriy in spermatocytes

abnormal male meiosis ( J:280261 )

• defective sister-chromatid cohesion in spermatocytes

• aberrant chromatin compaction with chromosomes occupying larger and more than one territories in spermatocytes

• reduced number (50% of WT) of recombination hotspots in leptotene-like spermatocytes

• increased representation of pre-leptonema to zygonema-like stage spermatocytes in testis

abnormal synaptonemal complex ( J:280261 )

• absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

increased male germ cell apoptosis ( J:280261 )

cellular

abnormal chromosomal synapsis ( J:280261 )

• aberrant homolog pairing with increased incidence of chromosomes occupying more than one territoriy in spermatocytes

abnormal male meiosis ( J:280261 )

• defective sister-chromatid cohesion in spermatocytes

• aberrant chromatin compaction with chromosomes occupying larger and more than one territories in spermatocytes

• reduced number (50% of WT) of recombination hotspots in leptotene-like spermatocytes

• increased representation of pre-leptonema to zygonema-like stage spermatocytes in testis

abnormal synaptonemal complex ( J:280261 )

• absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

increased male germ cell apoptosis ( J:280261 )

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (66% of WT) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (66% of WT) in spermatocytes

Allelic Composition	Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Stag3^{tm1e.1(KOMP)Wtsi}/J
Cell Lines	EPD0505_4_B10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stag3^{tm1e.1(KOMP)Wtsi} mutation (1 available); any Stag3 mutation (54 available)

Data Sources

IMPC Data for Stag3

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - JAX

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - JAX

endocrine/exocrine glands

small testis ( J:211773 )

IMPC - JAX

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - JAX

reproductive system

small testis ( J:211773 )

IMPC - JAX

female infertility ( J:211773 )

IMPC - JAX

male infertility ( J:211773 )

IMPC - JAX

skeleton

abnormal bone structure ( J:211773 )

IMPC - JAX

decreased bone mineral content ( J:211773 )

IMPC - JAX

decreased bone mineral density ( J:211773 )

IMPC - JAX

Allelic Composition	Prdm9^tm1Ymat/Prdm9^tm1Ymat Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
Genetic Background	B6.Cg-Prdm9^tm1Ymat Stag3^{tm1e.1(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm9^tm1Ymat mutation (3 available); any Prdm9 mutation (46 available)
Stag3^{tm1e.1(KOMP)Wtsi} mutation (1 available); any Stag3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:280261 )

• reduced number (30% of WT, 27-56% of either single KO) of recombination hotspots in leptotene-like spermatocytes

cellular

abnormal male meiosis ( J:280261 )

• reduced number (30% of WT, 27-56% of either single KO) of recombination hotspots in leptotene-like spermatocytes

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (20-30% of WT or either single KO) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (20-30% of WT or either single KO) in spermatocytes

Allelic Composition	Spo11^tm1Mjn/Spo11⁺ Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
Genetic Background	B6.Cg-Spo11^tm1Mjn Stag3^{tm1e.1(KOMP)Wtsi}/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spo11^tm1Mjn mutation (2 available); any Spo11 mutation (20 available)
Stag3^{tm1e.1(KOMP)Wtsi} mutation (1 available); any Stag3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal double-strand DNA break repair ( J:280261 )

• complete absence of double-strand DNA breaks in 77% of zygotene spermatocytes and 50% reduction (compared to either single KO) in remaining 23% of spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

• complete absence of double-strand DNA breaks in 77% of zygotene spermatocytes and 50% reduction (compared to either single KO) in remaining 23% of spermatocytes

Allelic Composition	Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
Genetic Background	B6N(Cg)-Rad21l^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21l^{tm1b(KOMP)Wtsi} mutation (1 available); any Rad21l mutation (34 available)
Stag3^{tm1e.1(KOMP)Wtsi} mutation (1 available); any Stag3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal synaptonemal complex ( J:280261 )

• absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

cellular

abnormal synaptonemal complex ( J:280261 )

• absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (77% of WT) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (77% of WT) in spermatocytes

Allelic Composition	Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
Genetic Background	B6N(Cg)-Rec8^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rec8^{tm1b(KOMP)Wtsi} mutation (1 available); any Rec8 mutation (25 available)
Stag3^{tm1e.1(KOMP)Wtsi} mutation (1 available); any Stag3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:280261 )

• reduced number (25% of WT, 42-61% of either single KO) of recombination hotspots in leptotene-like spermatocytes

abnormal synaptonemal complex ( J:280261 )

• absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

cellular

abnormal male meiosis ( J:280261 )

• reduced number (25% of WT, 42-61% of either single KO) of recombination hotspots in leptotene-like spermatocytes

abnormal synaptonemal complex ( J:280261 )

• absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (40% of either single KO or 60% of WT) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (40% of either single KO or 60% of WT) in spermatocytes

Allelic Composition	Prdm9^em3Kpgn/Prdm9^em3Kpgn Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm9^em3Kpgn mutation (0 available); any Prdm9 mutation (46 available)
Stag3^{tm1e.1(KOMP)Wtsi} mutation (1 available); any Stag3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal double-strand DNA break repair ( J:280261 )

• severely reduced number of double-strand DNA breaks in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

• severely reduced number of double-strand DNA breaks in spermatocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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