Phenotypes associated with this allele

• Allele Symbol: Pds5a^tm1.1Alos
• Allele Name: targeted mutation 1.1, Ana Losada
• Allele ID: MGI:5563475
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pds5a^tm1.1Alos/Pds5a^tm1.1Alos	involves: 129S2/SvPas	MGI:5563519

Genotype
MGI:5563519

hm1

• Allelic Composition: Pds5a^tm1.1Alos/Pds5a^tm1.1Alos
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:205601 )

• fewer than expected mice are present between E16.5 and E18.5

skeleton

delayed endochondral bone ossification ( J:205601 )

• in the vertebral column

failure of intramembranous bone ossification ( J:205601 )

integument

decreased hair follicle number ( J:205601 )

abnormal skin morphology ( J:205601 )

• the keratin layer in the skin is almost absent with disorganized skin layers

growth/size/body

decreased fetal size ( J:205601 )

• general hypoplasia

fetal growth retardation ( J:205601 )

adipose tissue

decreased brown adipose tissue amount ( J:205601 )

• thinner interscapular brown adipose tissue deposits

cellular

abnormal mitosis ( J:205601 )

• mouse embryonic fibroblasts exhibit a larger fraction of G1 cells and a smaller fraction of cells in S phase compared with wild-type cells

nervous system

abnormal cerebellum fissure morphology ( J:205601 )

• only 1 fissure is observed