Pds5a^tm1.1Alos
Targeted Allele Detail

Summary

• Symbol: Pds5a^tm1.1Alos
• Name: PDS5 cohesin associated factor A; targeted mutation 1.1, Ana Losada
• MGI ID: MGI:5563475
• Gene: Pds5a Location: Chr5:65763062-65855579 bp, - strand Genetic Position: Chr5, 33.76 cM, cytoband C3.3
• Alliance: Pds5a^tm1.1Alos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205601
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele contains an FRT-flanked neomycin resistance cassette and two loxP sites flanking this cassette and exon 6. Cre-mediated recombination removed the selection cassette and exon 6. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:205601)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pds5a Mutation: 81 strains or lines available

References

• Original: J:205601 Carretero M, et al., Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres. EMBO J. 2013 Nov 13;32(22):2938-49
• All: 2 reference(s)