Phenotypes associated with this allele

• Allele Symbol: Cd72^b
• Allele Name: b haplotype
• Allele ID: MGI:5563237
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cd72^b/Cd72^b Fas^lpr/Fas^lpr	involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp	MGI:5563354

Genotype
MGI:5563354

cx1

• Allelic Composition: Cd72^b/Cd72^b; Fas^lpr/Fas^lpr
• Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell number ( J:204782 )

• increased percentage of total B cells in the spleen compared with Fas^lpr homozygotes on a MRL background

abnormal T cell number ( J:204782 )

• reduced percentage of lpr T cells in the spleen compared with Fas^lpr homozygotes on a MRL background

• increased percentage of total T cells in the spleen compared with Fas^lpr homozygotes on a MRL background

decreased spleen weight ( J:204782 )

• compared with Fas^lpr homozygotes on a MRL background

decreased IgG level ( J:204782 )

• compared with Fas^lpr homozygotes on a MRL background

autoimmune response ( J:204782 )

decreased susceptibility to autoimmune disorder ( J:204782 )

• less severe autoimmune disease (reduced spleen weight, reduced percentage of lpr T cells in the spleen, decreased nuclear autoantibodies, reduced glomeruli size, reduced grade of proteinuria and reduced immune complex deposition) compared with Fas^lpr homozygotes on a MRL background

• however, severity of renal disease is the same as in Fas^lpr homozygotes on a MRL background

decreased anti-nuclear antigen antibody level ( J:204782 )

• anti-double- and single-stranded autoantibodies compared with Fas^lpr homozygotes on a MRL background

decreased anti-double stranded DNA antibody level ( J:204782 )

• compared with Fas^lpr homozygotes on a MRL background

renal/urinary system

abnormal urine protein level ( J:204782 )

• reduced proteinuria compared with Fas^lpr homozygotes on a MRL background

abnormal renal glomerulus morphology ( J:204782 )

• decreased size and immune complex deposition compared with Fas^lpr homozygotes on a MRL background

renal glomerular protein deposits ( J:204782 )

homeostasis/metabolism

abnormal urine protein level ( J:204782 )

• reduced proteinuria compared with Fas^lpr homozygotes on a MRL background

hematopoietic system

abnormal B cell number ( J:204782 )

• increased percentage of total B cells in the spleen compared with Fas^lpr homozygotes on a MRL background

abnormal T cell number ( J:204782 )

• reduced percentage of lpr T cells in the spleen compared with Fas^lpr homozygotes on a MRL background

• increased percentage of total T cells in the spleen compared with Fas^lpr homozygotes on a MRL background

decreased spleen weight ( J:204782 )

• compared with Fas^lpr homozygotes on a MRL background

decreased IgG level ( J:204782 )

• compared with Fas^lpr homozygotes on a MRL background