All Phenotypes Rnf7<tm1.1Ysun> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rnf7^tm1.1Ysun
targeted mutation 1.1, Yi Sun
MGI:5562909

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kras^tm4Tyj/Kras⁺ Rnf7^Gt(XE423)Byg/Rnf7^tm1.1Ysun	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5562910

Allelic Composition	Kras^tm4Tyj/Kras⁺ Rnf7^Gt(XE423)Byg/Rnf7^tm1.1Ysun
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Rnf7^Gt(XE423)Byg mutation (0 available); any Rnf7 mutation (17 available)
Rnf7^tm1.1Ysun mutation (0 available); any Rnf7 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:207982 )

• median survival time of Ad-Cre treated mice is 37.9 weeks, with most mice dying by 60 weeks

neoplasm

decreased lung tumor incidence ( J:207982 )

• mice show reduced lung tumor burden following intratracheal administration of an adenovirus expressing Cre (Ad-Cre) compared to single Kras homozygotes, however the number of hyperplastic loci is not affected

• hyperplasia or adenomas from Ad-Cre treated mice show reduced proliferation compared to single Kras homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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