Analysis Tools
mortality/aging
| N |
• mice exhibit normal survival up to 1 year
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immune system
| N |
• neutrophils, B cells, T cells and B-1b cells exhibit normal uptake of apoptotic cells
|
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• macrophage cells are less able to acquire dye-labeled apoptotic cells compared with wild-type macrophage cells
• however, restoring expression restores capture ability
|
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• activated lymphocytes in the spleen of mice over 20 weeks of age
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• in the spleen of mice over 20 weeks of age
|
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• in the spleen of mice over 20 weeks of age
• CD44+ and CXCR5+Blimp1- Bacl6+CD4+ follicular helper T cells in the spleen of mice over 20 weeks of age
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• CXCR5+Blimp1- Bacl6+CD4+ follicular helper T cells in the spleen of mice over 20 weeks of age
|
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• apoptotic cells accumulate in the spleen
|
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• in mice over 20 weeks of age
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• in mice over 20 weeks of age
|
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• B-1a cells are less able to acquire dye-labeled apoptotic cells compared with wild-type B-1a cells
• however, uptake of apoptotic cells is normal in B and B-1b cells
|
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• in the serum of mice over 20 weeks of age
|
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• CD8alpha dendritic cells are less able to acquire dye-labeled apoptotic cells in vitro and in vivo compared with wild-type dendritic cells
• however, restoring expression restores capture ability
|
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• skin disease and lupus nephritis
|
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• in the serum at 20 weeks (higher in female mice compared with male mice)
|
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• with increased glomerular size, cellularity and IgG deposition at 24 weeks
• more severe in female than male mice
|
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• accompanied by hair loss and whisker loss at 20 weeks
• more severe in female mice than male mice
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renal/urinary system
|
• moderate
|
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• with increased glomerular size, cellularity and IgG deposition at 24 weeks
• more severe in female than male mice
|
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• IgG deposits at 24 weeks
|
integument
|
• accompanied by hair loss and whisker loss at 20 weeks
• more severe in female mice than male mice
|
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• with skin inflammation at 20 weeks
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cellular
| N |
• the frequency of apoptosis of splenocytes, B cells and bone marrow cells is normal
|
|
• endothelial cells are less able to acquire dye-labeled apoptotic cells compared with wild-type endothelial cells
• however, restoring expression restores capture ability
|
|
• macrophage cells are less able to acquire dye-labeled apoptotic cells compared with wild-type macrophage cells
• however, restoring expression restores capture ability
|
homeostasis/metabolism
|
• moderate
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hematopoietic system
|
• macrophage cells are less able to acquire dye-labeled apoptotic cells compared with wild-type macrophage cells
• however, restoring expression restores capture ability
|
|
• activated lymphocytes in the spleen of mice over 20 weeks of age
|
|
• in the spleen of mice over 20 weeks of age
|
|
• in the spleen of mice over 20 weeks of age
• CD44+ and CXCR5+Blimp1- Bacl6+CD4+ follicular helper T cells in the spleen of mice over 20 weeks of age
|
|
• CXCR5+Blimp1- Bacl6+CD4+ follicular helper T cells in the spleen of mice over 20 weeks of age
|
|
• apoptotic cells accumulate in the spleen
|
|
• in mice over 20 weeks of age
|
|
• in mice over 20 weeks of age
|
|
• B-1a cells are less able to acquire dye-labeled apoptotic cells compared with wild-type B-1a cells
• however, uptake of apoptotic cells is normal in B and B-1b cells
|
|
• in the serum of mice over 20 weeks of age
|
growth/size/body
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• in mice over 20 weeks of age
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