Phenotypes associated with this allele

• Allele Symbol: Sorcs3^tm1.1Tew
• Allele Name: targeted mutation 1.1, Thomas E Willnow
• Allele ID: MGI:5562419
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sorcs3^tm1.1Tew/Sorcs3^tm1.1Tew	B6N.Cg-Sorcs3^tm1.1Tew	MGI:5562420

Genotype
MGI:5562420

hm1

• Allelic Composition: Sorcs3^tm1.1Tew/Sorcs3^tm1.1Tew
• Genetic Background: B6N.Cg-Sorcs3^tm1.1Tew

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:207532 )

N • mice exhibit normal behavior in an open field

impaired avoidance learning behavior ( J:207532 )

• impaired acquisition of fear memory with accelerated extinction of short-term fear memory

impaired spatial learning ( J:207532 )

• in the Barnes maze

abnormal spatial working memory ( J:207532 )

• impaired in the Barnes maze

nervous system

nervous system phenotype ( J:207532 )

N • mice exhibit normal long term potentiation and paired-pulse facilitation

absent long-term depression ( J:207532 )

• NMDA and glutamate receptor-dependent