Sorcs3^tm1.1Tew
Targeted Allele Detail

Summary

• Symbol: Sorcs3^tm1.1Tew
• Name: sortilin-related VPS10 domain containing receptor 3; targeted mutation 1.1, Thomas E Willnow
• MGI ID: MGI:5562419
• Gene: Sorcs3 Location: Chr19:48194464-48793944 bp, + strand Genetic Position: Chr19, 41.32 cM
• Alliance: Sorcs3^tm1.1Tew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207532
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the selection cassette. Western blot analysis confirmed the absence of protein expression in the hippocampus, cortex and cerebellum. (J:207532)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sorcs3 Mutation: 65 strains or lines available

References

• Original: J:207532 Breiderhoff T, et al., Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS One. 2013;8(9):e75006
• All: 2 reference(s)