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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd274tm1Igu
targeted mutation 1, Indira Guleria
MGI:5562292
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Cd274tm1Igu/Cd274+ involves: 129 * C57BL/6 * CBA/CaJ MGI:5562293
cx2
 		Cd274tm1Igu/Cd274tm1Igu
Vsirtm1Lex/Vsirtm1Lex 		involves: 129S5/SvEvBrd * C57BL/6 MGI:5770301


Genotype
MGI:5562293
ht1
Allelic
Composition		 Cd274tm1Igu/Cd274+
Genetic
Background		 involves: 129 * C57BL/6 * CBA/CaJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd274tm1Igu mutation (0 available); any Cd274 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:100544 )
• when homozygous females on a 129 and C57BL/6 background are mated to wild-type males on a CBA/CaJ background, a reduction in heterozygous fetal survival rates is seen




Genotype
MGI:5770301
cx2
Allelic
Composition		 Cd274tm1Igu/Cd274tm1Igu
Vsirtm1Lex/Vsirtm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd274tm1Igu mutation (0 available); any Cd274 mutation (71 available)
Vsirtm1Lex mutation (2 available); any Vsir mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell activation ( J:222944 )
• spontaneous activation of peripheral CD4+ and CD8+ T cells

immune system
abnormal T cell activation ( J:222944 )
• spontaneous activation of peripheral CD4+ and CD8+ T cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory