Cd274^tm1Igu
Targeted Allele Detail

Summary

• Symbol: Cd274^tm1Igu
• Name: CD274 antigen; targeted mutation 1, Indira Guleria
• MGI ID: MGI:5562292
• Synonyms: PDL1^-
• Gene: Cd274 Location: Chr19:29344855-29365495 bp, + strand Genetic Position: Chr19, 23.88 cM, cytoband C2
• Alliance: Cd274^tm1Igu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100544
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A 0.8-kb sequence involving exons 2 and 3 was deleted and replaced by a neo cassette. (J:100544)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd274 Mutation: 71 strains or lines available

References

• Original: J:100544 Guleria I, et al., A critical role for the programmed death ligand 1 in fetomaternal tolerance. J Exp Med. 2005 Jul 18;202(2):231-7
• All: 4 reference(s)