Phenotypes associated with this allele

• Allele Symbol: Mirc31^tm1.1Aru
• Allele Name: targeted mutation 1.1, Anil K Rustgi
• Allele ID: MGI:5560203
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mirc31^tm1.1Aru/Mirc31^tm1.1Aru Tg(Vil1-cre)997Gum/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL	MGI:5560214
cn2	Mirc31^tm1.1Aru/Mirc31^tm1.1Aru Tg(Vil1-cre)997Gum/0 Tg(Vil1-Lin28b,-tdTomato)LoAru/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL	MGI:5560215

Genotype
MGI:5560214

cn1

• Allelic Composition: Mirc31^tm1.1Aru/Mirc31^tm1.1Aru; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestine morphology ( J:202923 )

• modest but significant intestinal hypertrophy

abnormal crypts of Lieberkuhn morphology ( J:202923 )

• increase in the fraction of fissile crypts

abnormal small intestine morphology ( J:202923 )

• thicker

decreased Paneth cell number ( J:202923 )

• modest decrease in the number of Paneth cells

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:202923 )

• increase in the fraction of fissile crypts

decreased Paneth cell number ( J:202923 )

• modest decrease in the number of Paneth cells

Genotype
MGI:5560215

cn2

• Allelic Composition: Mirc31^tm1.1Aru/Mirc31^tm1.1Aru; Tg(Vil1-cre)997Gum/0; Tg(Vil1-Lin28b,-tdTomato)LoAru/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:202923 )

• crypt hyperplasia and expanded crypts

decreased Paneth cell number ( J:202923 )

• significant reduction in the number of Paneth cells

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:202923 )

• crypt hyperplasia and expanded crypts

decreased Paneth cell number ( J:202923 )

• significant reduction in the number of Paneth cells