Phenotypes associated with this allele

• Allele Symbol: Rtel1^tm2.1Hdin
• Allele Name: targeted mutation 2.1, Hao Ding
• Allele ID: MGI:5559530
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rtel1^tm2.1Hdin/Rtel1^tm2.1Hdin	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5559533
cx2	Rtel1^tm2.1Hdin/Rtel1^tm2.1Hdin Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:5559534

Genotype
MGI:5559533

hm1

• Allelic Composition: Rtel1^tm2.1Hdin/Rtel1^tm2.1Hdin
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:202812 )

N • mouse embryonic fibroblasts exhibit normal telomere length distribution and sister chromatid exchange

abnormal telomere morphology ( J:202812 )

• fragile telomeres in mouse embryonic fibroblasts

abnormal cell physiology ( J:202812 )

• mouse embryonic fibroblasts exhibit increased spontaneous DNA damage compared with control cells

abnormal mitosis ( J:202812 )

• mouse embryonic fibroblasts accumulate in the late S/G2 unlike control cells

early cellular replicative senescence ( J:202812 )

• in mouse embryonic fibroblasts

decreased DNA replication ( J:202812 )

• decreased fork speed and instability in mouse embryonic fibroblasts

homeostasis/metabolism

decreased DNA replication ( J:202812 )

• decreased fork speed and instability in mouse embryonic fibroblasts

Genotype
MGI:5559534

cx2

• Allelic Composition: Rtel1^tm2.1Hdin/Rtel1^tm2.1Hdin; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

mortality/aging

premature death ( J:202812 )

• compared with Rtel1^tm2.1Hdin/Rtel1⁺ Trp53^tm1Tyj/Trp53^tm1Tyj mice

neoplasm

increased lymphoma incidence ( J:202812 )

• as in Trp53^tm1Tyj homozygotes

increased medulloblastoma incidence ( J:202812 )

• unlike in Trp53^tm1Tyj homozygotes

increased sarcoma incidence ( J:202812 )

• as in Trp53^tm1Tyj homozygotes

increased teratoma incidence ( J:202812 )

• as in Trp53^tm1Tyj homozygotes

decreased tumor latency ( J:202812 )

• tumor formation occurs within 115+/-31 days compared with 147+/-35 days for Rtel1^tm2.1Hdin/Rtel1⁺ Trp53^tm1Tyj/ Trp53^tm1Tyj mice

cellular

abnormal telomere morphology ( J:202812 )

• extensive sister chromatid fusions, end-to-end fusions with telomeric repeats and fragile telomeres in tumor cells unlike in tumor cells from Trp53^tm1Tyj homozygotes

nervous system

increased medulloblastoma incidence ( J:202812 )

• unlike in Trp53^tm1Tyj homozygotes