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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-COL4A3/Col4a3)#aJhm
transgene insertion #a, Jeffrey H Miner
MGI:5559154
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Col4a3tm1Jhm/Col4a3tm1Jhm
Tg(Nphs1-rtTA*3G)8Jhm/0
Tg(tetO-COL4A3/Col4a3)#aJhm/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5559180
cx2
 		Col4a3tm1Jhm/Col4a3tm1Jhm
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(tetO-COL4A3/Col4a3)#aJhm/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5559181


Genotype
MGI:5559180
cx1
Allelic
Composition		 Col4a3tm1Jhm/Col4a3tm1Jhm
Tg(Nphs1-rtTA*3G)8Jhm/0
Tg(tetO-COL4A3/Col4a3)#aJhm/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col4a3tm1Jhm mutation (1 available); any Col4a3 mutation (60 available)
Tg(Nphs1-rtTA*3G)8Jhm mutation (0 available)
Tg(tetO-COL4A3/Col4a3)#aJhm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:207595 )
N
• doxycycline-treated mice survive beyond 32 weeks unlike Col4a3tm1Jhm homozygotes

renal/urinary system
renal/urinary system phenotype ( J:207595 )
N
• doxycycline-treated mice remain nonalbuminuric for months unlike Col4a3tm1Jhm homozygotes
• doxycycline-treated mice do not exhibit glomerulosclerosis or tubular protein cast unlike Col4a3tm1Jhm homozygotes
abnormal podocyte foot process morphology ( J:207595 )
• some doxycycline-treated mice do not maintain podocyte foot process architecture
• however, many doxycycline-treated mice maintain podocyte foot process architecture unlike in Col4a3tm1Jhm homozygotes
abnormal renal glomerulus basement membrane morphology ( J:207595 )
• doxycycline-treated mice exhibit some blebs on the glomerulus basement membrane
increased renal glomerulus basement membrane thickness ( J:207595 )
• doxycycline-treated mice exhibit some of segmental glomerulus basement membrane thickening observed in Col4a3tm1Jhm homozygotes




Genotype
MGI:5559181
cx2
Allelic
Composition		 Col4a3tm1Jhm/Col4a3tm1Jhm
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(tetO-COL4A3/Col4a3)#aJhm/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col4a3tm1Jhm mutation (1 available); any Col4a3 mutation (60 available)
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation (5 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(tetO-COL4A3/Col4a3)#aJhm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:207595 )
N
• doxycycline-treated mice exhibit normal kidney architecture
increased renal glomerulus basement membrane thickness ( J:207595 )
• doxycycline-treated mice exhibit some of segmental glomerulus basement membrane thickening observed in Col4a3tm1Jhm homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory