All Phenotypes Megf8<tm1.2Ddg> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Megf8^tm1.2Ddg
targeted mutation 1.2, David D Ginty
MGI:5558931

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Megf8^tm1.2Ddg/Megf8^tm1.2Ddg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S6/SvEvTac * C57BL/6J * CBA/J	MGI:5558940
cn2	Megf8^tm1.2Ddg/Megf8^tm1.2Ddg Mesp1^tm2(cre)Ysa/Mesp1⁺	involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj	MGI:5558939

Allelic Composition	Megf8^tm1.2Ddg/Megf8^tm1.2Ddg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)
Megf8^tm1.2Ddg mutation (1 available); any Megf8 mutation (97 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:206541 )

N	• radial and ulnar nerve development is normal

abnormal axon fasciculation ( J:206541 )

• defasciculation of the ophthalmic branch of the trigeminal nerve but more variable than in null mice

abnormal ophthalmic nerve morphology ( J:206541 )

• defasciculation of the ophthalmic branch of the trigeminal nerve but more variable than in null mice

limbs/digits/tail

limbs/digits/tail phenotype ( J:206541 )

N	• mice exhibit normal limb maturity

cellular

abnormal axon fasciculation ( J:206541 )

• defasciculation of the ophthalmic branch of the trigeminal nerve but more variable than in null mice

Allelic Composition	Megf8^tm1.2Ddg/Megf8^tm1.2Ddg Mesp1^tm2(cre)Ysa/Mesp1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Megf8^tm1.2Ddg mutation (1 available); any Megf8 mutation (97 available)
Mesp1^tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:206541 )

N	• mice exhibit a normal heart phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24