All Phenotypes Megf8<tm1.2Ddg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Megf8^tm1.2Ddg
targeted mutation 1.2, David D Ginty
MGI:5558931

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Megf8^tm1.2Ddg/Megf8^tm1.2Ddg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S6/SvEvTac * C57BL/6J * CBA/J	MGI:5558940
cn2	Megf8^tm1.2Ddg/Megf8^tm1.2Ddg Mesp1^tm2(cre)Ysa/Mesp1⁺	involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj	MGI:5558939

Allelic Composition	Megf8^tm1.2Ddg/Megf8^tm1.2Ddg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Megf8^tm1.2Ddg mutation (1 available); any Megf8 mutation (96 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:206541 )

N	• radial and ulnar nerve development is normal

abnormal axon fasciculation ( J:206541 )

• defasciculation of the ophthalmic branch of the trigeminal nerve but more variable than in null mice

abnormal ophthalmic nerve morphology ( J:206541 )

• defasciculation of the ophthalmic branch of the trigeminal nerve but more variable than in null mice

limbs/digits/tail

limbs/digits/tail phenotype ( J:206541 )

N	• mice exhibit normal limb maturity

cellular

abnormal axon fasciculation ( J:206541 )

• defasciculation of the ophthalmic branch of the trigeminal nerve but more variable than in null mice

Allelic Composition	Megf8^tm1.2Ddg/Megf8^tm1.2Ddg Mesp1^tm2(cre)Ysa/Mesp1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Megf8^tm1.2Ddg mutation (1 available); any Megf8 mutation (96 available)
Mesp1^tm2(cre)Ysa mutation (1 available); any Mesp1 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:206541 )

N	• mice exhibit a normal heart phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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