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Allele Symbol Allele Name Allele ID |
Il6ratm1.1(IL6R)Csk targeted mutation 1.1, Chugai Pharmaceutical Co Ltd MGI:5556081 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased in response to human IL6 but not mouse IL6 unlike in wild-type mice that respond to both
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• increased in response to human IL6 but not mouse IL6 unlike in wild-type mice that respond to both
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• prior to and after treatment with MR16-1
• however, treatment with tocilizumab prevents development of splenomegaly
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• however, treatment with tocilizumab prevents development of splenomegaly
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• in the spleen
• however, treatment with ameliorates histological observations
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• however, treatment with ameliorates histological observations
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• prior to and after treatment with MR16-1
• however, treatment with tocilizumab prevents development of splenomegaly
|
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• however, treatment with tocilizumab prevents development of splenomegaly
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• in the spleen
• however, treatment with ameliorates histological observations
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• however, treatment with ameliorates histological observations
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• prior to and after treatment with MR16-1
• however, treatment with tocilizumab prevents development of splenomegaly
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• however, treatment with tocilizumab prevents development of splenomegaly
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| lymphoproliferative syndrome | DOID:0060704 |
OMIM:PS308240 |
J:207264 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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