Il6ra^{tm1.1(IL6R)Csk}
Targeted Allele Detail

Summary

• Symbol: Il6ra^{tm1.1(IL6R)Csk}
• Name: interleukin 6 receptor, alpha; targeted mutation 1.1, Chugai Pharmaceutical Co Ltd
• MGI ID: MGI:5556081
• Synonyms: Il6ra^hIL6R, Il6ra^{tm1(hIL6R)Csk}
• Gene: Il6ra Location: Chr3:89776631-89820503 bp, - strand Genetic Position: Chr3, 39.19 cM
• Alliance: Il6ra^{tm1.1(IL6R)Csk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207264
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence of exon 1 was replaced with the human cDNA and a floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. (J:207264)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il6ra Mutation: 35 strains or lines available

References

• Original: J:207264 Ueda O, et al., Novel genetically-humanized mouse model established to evaluate efficacy of therapeutic agents to human interleukin-6 receptor. Sci Rep. 2013;3:1196
• All: 1 reference(s)