Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Fos)Wag mutation
(0 available);
any
Col1a1 mutation
(160 available)
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation
(5 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Alb1-cre)7Gsc mutation
(1 available)
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mortality/aging
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• doxycycline-treated mice develop lethal liver dysplasia
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liver/biliary system
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• doxycycline-treated mice develop lethal liver dysplasia
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Fos)Wag mutation
(0 available);
any
Col1a1 mutation
(160 available)
Rag1tm1Mom mutation
(49 available);
any
Rag1 mutation
(120 available)
Tg(KRT5-rtTA)T2D6Sgkd mutation
(1 available)
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integument
N |
• doxycycline-treated mice exhibit normal keratinocyte proliferation and activation
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• in doxycycline-treated mice but smaller than in mice with wild-type Rag1
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• in doxycycline-treated mice but less so than in mice with wild-type Rag1
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Fos)Wag mutation
(0 available);
any
Col1a1 mutation
(160 available)
Tg(KRT5-rtTA)T2D6Sgkd mutation
(1 available)
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mortality/aging
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• after doxycycline treatment
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integument
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• with increased survival in doxycycline-treated mice
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• in doxycycline-treated mice
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• after doxycycline treatment
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• in doxycycline-treated mice
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• cornified epidermis in affected skin of doxycycline-treated mice
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• in doxycycline-treated mice
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• in doxycycline-treated mice
• however, MMP inhibitor impairs hyperplasia
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• dry and scaly lesions on the affected skin of doxycycline-treated mice
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• in doxycycline-treated mice
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• affected skin of doxycycline-treated mice
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immune system
N |
• doxycycline-treated mice exhibit normal spleen weight
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• in the skin of doxycycline-treated mice
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• in the skin of doxycycline-treated mice
• however, doxycycline withdrawal restores CD4+ T cell numbers
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• in doxycycline-treated mice
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neoplasm
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• doxycycline-treated mice exposed to DMBA/TPA develop papillomas at 8 weeks that become ulcerative at 11 weeks
• however, sulindac treatment reduces the number and size of tumors
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• doxycycline-treated mice exposed to DMBA/TPA develop papillomas at 8 weeks that become ulcerative at 11 weeks
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growth/size/body
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• after doxycycline treatment
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digestive/alimentary system
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• mild phenotype in doxycycline-treated mice
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homeostasis/metabolism
cellular
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• with increased survival in doxycycline-treated mice
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hematopoietic system
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• in the skin of doxycycline-treated mice
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• in the skin of doxycycline-treated mice
• however, doxycycline withdrawal restores CD4+ T cell numbers
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