Phenotypes associated with this allele

• Allele Symbol: Tshr^hyt-3J
• Allele Name: hypothyroid 3 Jackson
• Allele ID: MGI:5554389
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tshr^hyt-3J/Tshr^hyt-3J	CByJ;CXB10-Tshr^hyt-3J/GrsrJ	MGI:5572808
hm2	Tshr^hyt-3J/Tshr^hyt-3J	CXB10/HiAJ-Tshr^hyt-3J/GrsrJ	MGI:5572798

Genotype
MGI:5572808

hm1

• Allelic Composition: Tshr^hyt-3J/Tshr^hyt-3J
• Genetic Background: CByJ;CXB10-Tshr^hyt-3J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased activity of thyroid gland ( J:210510 )

growth/size/body

proportional dwarf ( J:210510 )

• homozygotes are approximately half the normal size

mortality/aging

lethality at weaning, incomplete penetrance ( J:210510 )

• many homozygotes die around 3 weeks of age, and if they survive through wean age will usually survive to adulthood and live a relatively normal lifespan

premature death ( J:210510 )

• there is some premature death in the adult population

prenatal lethality, incomplete penetrance ( J:210510 )

• heterozygous intercrosses produce fewer than the expected 25% homozygotes

reproductive system

reduced female fertility ( J:210510 )

♀ • decreased fertility compared with wild-type controls

reduced male fertility ( J:210510 )

♂ • Background Sensitivity: with increased BALB/cByJ in the background some male homozygotes will breed, but fertility is still decreased relative to wild-type littermates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital hypothyroidism		DOID:0050328	OMIM:PS275200	J:210510

Genotype
MGI:5572798

hm2

• Allelic Composition: Tshr^hyt-3J/Tshr^hyt-3J
• Genetic Background: CXB10/HiAJ-Tshr^hyt-3J/GrsrJ

growth/size/body

proportional dwarf ( J:210510 )

• homozygotes are approximately half the normal size

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:210510 )

• Two of two homozygotes assessed at four and a half weeks of age showed elevated thresholds at all frequencies whereas wildtype controls had elevated frequencies only at 32 kHz

reproductive system

reduced female fertility ( J:210510 )

♀ • compared with controls homozygous females have reduced fertility, but many do breed without hormone supplements when crossed to BALB/cByJ males

reduced male fertility ( J:210510 )

♂ • only one male homozygote bred on this CXB10/HiAJ background, but when bred further to BALB/cByJ male homozygous fertility improves

endocrine/exocrine glands

decreased activity of thyroid gland ( J:210510 )

mortality/aging

lethality at weaning, incomplete penetrance ( J:210510 )

• many homozygotes die around 3 weeks of age, and if they survive through wean age will usually survive to adulthood and live a relatively normal lifespan

premature death ( J:210510 )

• there is some premature death in the adult population

prenatal lethality, incomplete penetrance ( J:210510 )

• heterozygous intercrosses produce fewer than the expected 25% homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital hypothyroidism		DOID:0050328	OMIM:PS275200	J:210510