Phenotypes associated with this allele

• Allele Symbol: Lrig2^tm1.1Hhed
• Allele Name: targeted mutation 1.1, Hakan Hedman
• Allele ID: MGI:5553453
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrig2^tm1.1Hhed/Lrig2^tm1.1Hhed	involves: 129 * C57BL/6 * FVB/N	MGI:5553454

Genotype
MGI:5553454

hm1

• Allelic Composition: Lrig2^tm1.1Hhed/Lrig2^tm1.1Hhed
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:205929 )

• due to illness even when food pellets are softened with water

growth/size/body

decreased body size ( J:205929 )

• in young mice

decreased body weight ( J:205929 )

• from 5 days until 12 to 15 weeks of age

behavior/neurological

lethargy ( J:205929 )

• in mice with general symptoms of illness

abnormal posture ( J:205929 )

• crouched in mice with general symptoms of illness

integument

abnormal coat appearance ( J:205929 )

• hackled fur in mice with general symptoms of illness

immune system

increased inflammatory response ( J:205929 )

♂ • purulent cystitis and pyelonephritis in one male mice

♂ • moderate accumulation of degenerative neutrophils in the lumen of the accessory genital glands with little or no evidence of epithelial damage in one male mice

neoplasm

decreased incidence of induced tumors ( J:205929 )

• mice are protected from PDGFB-induced glioma

cellular

cellular phenotype ( J:205929 )

N • growth-arrested primary mouse embryonic fibroblasts exhibit normal primary cilia formation