All Phenotypes Rhbdf1<tm1.1Mfm> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rhbdf1^tm1.1Mfm
targeted mutation 1.1, Matthew Freeman
MGI:5551620

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm	B6.129S-Rhbdf1^tm1.1Mfm	MGI:5551635
hm2	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm	involves: 129S/SvEv * 129S6/SvEvTac	MGI:5551633
hm3	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J	MGI:5551634
cx4	Rhbdf1^tm1.1Mfm/Rhbdf1⁺ Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm	involves: 129S/SvEv * 129S6/SvEvTac	MGI:5551636
cx5	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm	involves: 129S/SvEv * 129S6/SvEvTac	MGI:5551638
cx6	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J	MGI:5551639
cx7	Rhbdf1^tm1.1Mfm/Rhbdf1⁺ Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J	MGI:5551637

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm
Genetic Background	B6.129S-Rhbdf1^tm1.1Mfm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhbdf1^tm1.1Mfm mutation (0 available); any Rhbdf1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:203951 )

• mice die between P9 and P20

behavior/neurological

ataxia ( J:203951 )

• with hind legs being particularly affected

impaired coordination ( J:203951 )

• uncoordinated with hind legs being particularly affected

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhbdf1^tm1.1Mfm mutation (0 available); any Rhbdf1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:203951 )

• mice survive 25 to 40 days

behavior/neurological

increased eating frequency ( J:203951 )

• obsessive eating around time of weaning

impaired coordination ( J:203951 )

• transient around 14 to 18 days

growth/size/body

decreased body weight ( J:203951 )

weight loss ( J:203951 )

• severe

nervous system

intracerebral hemorrhage ( J:203951 )

cardiovascular system

intracerebral hemorrhage ( J:203951 )

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhbdf1^tm1.1Mfm mutation (0 available); any Rhbdf1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:203951 )

• mice die by P60

postnatal lethality, incomplete penetrance ( J:203951 )

endocrine/exocrine glands

abnormal pancreatic acinus morphology ( J:203951 )

• pale

absent pancreatic acinar cell zymogen granule ( J:203951 )

pancreatic acinar hypoplasia ( J:203951 )

small thymus ( J:203951 )

hematopoietic system

hematopoietic system phenotype ( J:203951 )

N	• erythroid, myeloid and megakaryocyte maturation appear normal

small thymus ( J:203951 )

decreased bone marrow cell number ( J:203951 )

small spleen ( J:203951 )

growth/size/body

decreased body weight ( J:203951 )

• small and malnourished 6 to 14 days after birth

slow postnatal weight gain ( J:203951 )

• mice fail to gain weight after birth

adipose tissue

decreased white adipose tissue amount ( J:203951 )

• absent

cardiovascular system

abnormal heart morphology ( J:203951 )

• evidence of myocardial infarction with thrombi in and around the ventricular septum close to the site of infarction

homeostasis/metabolism

abnormal cardiac thrombosis ( J:203951 )

• thrombi in and around the ventricular septum close to the site of myocardial infarction

digestive/alimentary system

abnormal pancreatic acinus morphology ( J:203951 )

• pale

absent pancreatic acinar cell zymogen granule ( J:203951 )

pancreatic acinar hypoplasia ( J:203951 )

immune system

small thymus ( J:203951 )

small spleen ( J:203951 )

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1⁺ Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhbdf1^tm1.1Mfm mutation (0 available); any Rhbdf1 mutation (41 available)
Rhbdf2^tm1.1Mfm mutation (1 available); any Rhbdf2 mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:203951 )

N	• mice are viable

reproductive system

reproductive system phenotype ( J:203951 )

N	• mice are fertile

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:203951 )

• no mice beyond E9.5 to E10.5

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:203951 )

• no mice beyond E9.5 to E10.5

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1⁺ Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:203951 )

N	• mice are viable

reproductive system

reproductive system phenotype ( J:203951 )

N	• mice are fertile

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24