Rhbdf2^tm1.1Mfm
Targeted Allele Detail

Summary

• Symbol: Rhbdf2^tm1.1Mfm
• Name: rhomboid 5 homolog 2; targeted mutation 1.1, Matthew Freeman
• MGI ID: MGI:5309177
• Synonyms: iRhom2^-
• Gene: Rhbdf2 Location: Chr11:116488991-116517786 bp, - strand Genetic Position: Chr11, Syntenic
• Alliance: Rhbdf2^tm1.1Mfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179654
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 9 via homologous recombination. Cre mediated recombination removed exons 4 - 9 and the neo cassette. (J:179654)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rhbdf2 Mutation: 84 strains or lines available

References

• Original: J:179654 Adrain C, et al., Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE. Science. 2012 Jan 13;335(6065):225-8
• All: 11 reference(s)