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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atat1tm1.2Phep
targeted mutation 1.2, Paul A Heppenstall
MGI:5549960
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atat1tm1.2Phep/Atat1tm1.2Phep involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J MGI:5549970


Genotype
MGI:5549970
hm1
Allelic
Composition
Atat1tm1.2Phep/Atat1tm1.2Phep
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atat1tm1.2Phep mutation (0 available); any Atat1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are viable

reproductive system
• in the cauda epididymis
• however, flagella contain 9+2 axoneme organization
• cytoplasmic droplets attached to the annulus of the tail
• increased apoptosis during spermatogenesis and in the seminiferous tubules
• from male mice
• male mice produce smaller than expected litters

behavior/neurological
N
• mice exhibit normal working memory, muscle strength, motor coordination, balance and thermal nociception
• mice spend slightly more time in the border area of an open field
• however, mice exhibit normal behavior in an elevated plus maze

cellular
• lack of K40 alpha-tubulin acetylation in the majority of tissues tested
• however, ciliated organelles are morphologically normal
• in the cauda epididymis
• however, flagella contain 9+2 axoneme organization
• cytoplasmic droplets attached to the annulus of the tail
• increased apoptosis during spermatogenesis and in the seminiferous tubules

hematopoietic system
N
• mice exhibit normal peripheral blood parameters

integument
N
• mice exhibit normal thermal nociception

endocrine/exocrine glands





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory