Phenotypes associated with this allele

• Allele Symbol: Selenbp1^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548951
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Selenbp1^tm1b(KOMP)Wtsi/Selenbp1^tm1b(KOMP)Wtsi	C57BL/6N-Selenbp1^tm1b(KOMP)Wtsi/Mbp	MGI:6115599
hm2	Selenbp1^tm1b(KOMP)Wtsi/Selenbp1^tm1b(KOMP)Wtsi	C57BL/6N-Selenbp1^tm1b(KOMP)Wtsi/Ucd	MGI:6263450
ht3	Selenbp1^tm1b(KOMP)Wtsi/Selenbp1^+	C57BL/6N-Selenbp1^tm1b(KOMP)Wtsi/Mbp	MGI:6115600

Genotype
MGI:6115599

hm1

• Allelic Composition: Selenbp1^{tm1b(KOMP)Wtsi}/Selenbp1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Selenbp1^{tm1b(KOMP)Wtsi}/Mbp
• Cell Lines: EPD0122_2_H01

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:255748 )

• elevated dimethylsulfide and dimethyl-sulfone levels in the blood

abnormal enzyme/coenzyme activity ( J:255748 )

• absent methanethiol oxidase activity in erythrocytes, muscle and brain

Genotype
MGI:6263450

hm2

• Allelic Composition: Selenbp1^{tm1b(KOMP)Wtsi}/Selenbp1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Selenbp1^{tm1b(KOMP)Wtsi}/Ucd
• Cell Lines: EPD0122_2_H01

Data Sources

IMPC Data for Selenbp1

hematopoietic system

decreased mean corpuscular hemoglobin concentration ( J:211773 )

♀

IMPC - UCD

increased mean corpuscular volume ( J:211773 )

♀

IMPC - UCD

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

♂

IMPC - UCD

increased circulating insulin level ( J:211773 )

♀

IMPC - UCD

decreased circulating phosphate level ( J:211773 )

IMPC - UCD

decreased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - UCD

decreased circulating serum albumin level ( J:211773 )

♂

IMPC - UCD

Genotype
MGI:6115600

ht3

• Allelic Composition: Selenbp1^{tm1b(KOMP)Wtsi}/Selenbp1⁺
• Genetic Background: C57BL/6N-Selenbp1^{tm1b(KOMP)Wtsi}/Mbp
• Cell Lines: EPD0122_2_H01

homeostasis/metabolism

abnormal blood homeostasis ( J:255748 )

• moderately elevated dimethylsulfide levels in the blood

abnormal enzyme/coenzyme activity ( J:255748 )

• intermediate reduction in methanethiol oxidase activity in erythrocytes, muscle and brain