Analysis Tools
behavior/neurological
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• in the open field habituation test, males show slightly increased activity levels
• however, males show normal fear conditioning
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endocrine/exocrine glands
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• males form normal islets but islet mass decreases with age; by 16 weeks of age, males show a reduction in islet number without differences in the total area of the pancreas and by 46 weeks of age, males show a reduction in both total islet number and total islet area
• however, the average islet size remains the same as in wild-type mice
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• about 50% reduction in pancreatic islets in males
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• basal insulin secretion from islets is normal, however in response to 20 mM glucose,mutant islets secrete less insulin
• however, males exhibit normal insulin sensitivity
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growth/size/body
| N |
• no differences in weight, percentage fat, or lean mass is seen
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hematopoietic system
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IMPC - HAR
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homeostasis/metabolism
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• basal insulin secretion from islets is normal, however in response to 20 mM glucose,mutant islets secrete less insulin
• however, males exhibit normal insulin sensitivity
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IMPC - HAR
(J:211773)
MGI
• males, but not females, show an elevation in plasma glucose levels at 16 and 39 weeks of age
(J:226537)
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• impaired glucose tolerance at 13, 16, and 28 weeks of age
• glucose levels in males are elevated at 60 min post-glucose load and fail to return to normal levels after 120 min, becoming progressively worse with age
• females show elevated glucose levels 60 min post-glucose load at both 16 and 28 weeks but levels return to normal after 120 min
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• urine shows presence of both kynurenic and xanthurenic acid
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liver/biliary system
| N |
• liver histology is normal
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renal/urinary system
| N |
• kidney histology is normal
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• urine shows presence of both kynurenic and xanthurenic acid
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