Phenotypes associated with this allele

• Allele Symbol: Cdk5rap3^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5548726
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk5rap3^tm1b(EUCOMM)Hmgu/Cdk5rap3^tm1b(EUCOMM)Hmgu	C57BL/6N-Cdk5rap3^tm1b(EUCOMM)Hmgu/Ieg	MGI:5797429
hm2	Cdk5rap3^tm1b(EUCOMM)Hmgu/Cdk5rap3^tm1b(EUCOMM)Hmgu	involves: C57BL/6N * FVB/N	MGI:6295907
ht3	Cdk5rap3^tm1b(EUCOMM)Hmgu/Cdk5rap3^+	C57BL/6N-Cdk5rap3^tm1b(EUCOMM)Hmgu/Ieg	MGI:6262094

Genotype
MGI:5797429

hm1

• Allelic Composition: Cdk5rap3^{tm1b(EUCOMM)Hmgu}/Cdk5rap3^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Cdk5rap3^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0516_2_A06

Data Sources

IMPC Data for Cdk5rap3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:6295907

hm2

• Allelic Composition: Cdk5rap3^{tm1b(EUCOMM)Hmgu}/Cdk5rap3^{tm1b(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N * FVB/N

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:272566 )

• mice die from E16.5 onward with none present at E18.5

liver/biliary system

abnormal cholangiocyte morphology ( J:272566 )

• impaired differentiation

abnormal hepatoblast differentiation ( J:272566 )

• at E16.5, fetal livers exhibit undifferentiated hepatocytes that lack polarity unlike in wild-type livers

small liver ( J:272566 )

• in the fetus

decreased liver weight ( J:272566 )

• at E16.5

liver hypoplasia ( J:272566 )

abnormal liver physiology ( J:272566 )

• increased apoptosis at E14.5 in cells

• however, hepatocytes exhibit normal survival

decreased hepatocyte proliferation ( J:272566 )

hematopoietic system

abnormal erythropoiesis ( J:272566 )

• impaired in fetuses

anemia ( J:272566 )

• profound in the fetus

increased nucleated erythrocyte cell number ( J:272566 )

• at E16.5 in the peripheral blood

decreased hematopoietic stem cell number ( J:272566 )

• at E14.5 in fetal livers

growth/size/body

fetal growth retardation ( J:272566 )

• at E14.5

cardiovascular system

hemorrhage ( J:272566 )

• at E14.5 onward

cellular

decreased hepatocyte proliferation ( J:272566 )

endocrine/exocrine glands

abnormal cholangiocyte morphology ( J:272566 )

• impaired differentiation

Genotype
MGI:6262094

ht3

• Allelic Composition: Cdk5rap3^{tm1b(EUCOMM)Hmgu}/Cdk5rap3⁺
• Genetic Background: C57BL/6N-Cdk5rap3^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0516_2_A06

Data Sources

IMPC Data for Cdk5rap3

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - HMGU

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

IMPC - HMGU

abnormal retina blood vessel morphology ( J:211773 )

IMPC - HMGU

decreased cardiac stroke volume ( J:211773 )

♂

IMPC - HMGU

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

♂

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HMGU

cataract ( J:211773 )

IMPC - HMGU

abnormal retina morphology ( J:211773 )

IMPC - HMGU

abnormal retina vasculature morphology ( J:211773 )

IMPC - HMGU

abnormal retina blood vessel morphology ( J:211773 )

IMPC - HMGU

abnormal vitreous body morphology ( J:211773 )

IMPC - HMGU

persistence of hyaloid vascular system ( J:211773 )

IMPC - HMGU