Phenotypes associated with this allele

• Allele Symbol: Smoc1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548713
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smoc1^tm1b(EUCOMM)Wtsi/Smoc1^tm1b(EUCOMM)Wtsi	C57BL/6N-Smoc1^tm1b(EUCOMM)Wtsi/H	MGI:5757742
ht2	Smoc1^tm1b(EUCOMM)Wtsi/Smoc1^+	C57BL/6N-Smoc1^tm1b(EUCOMM)Wtsi/H	MGI:5797827

Genotype
MGI:5757742

hm1

• Allelic Composition: Smoc1^{tm1b(EUCOMM)Wtsi}/Smoc1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Smoc1^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0348_1_C03

Data Sources

IMPC Data for Smoc1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired pupillary reflex ( J:211773 )

♀

IMPC - HAR

abnormal gait ( J:211773 )

IMPC - HAR

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

♂

IMPC - HAR

abnormal retina blood vessel morphology ( J:211773 )

♀

IMPC - HAR

craniofacial

abnormal cranium morphology ( J:211773 )

IMPC - HAR

abnormal maxilla morphology ( J:211773 )

IMPC - HAR

abnormal snout morphology ( J:211773 )

IMPC - HAR

growth/size/body

abnormal maxilla morphology ( J:211773 )

IMPC - HAR

abnormal snout morphology ( J:211773 )

IMPC - HAR

abnormal head size ( J:211773 )

♀

IMPC - HAR

hematopoietic system

increased neutrophil cell number ( J:211773 )

♀

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♀

IMPC - HAR

immune system

increased neutrophil cell number ( J:211773 )

♀

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♀

IMPC - HAR

limbs/digits/tail

abnormal digit morphology ( J:211773 )

IMPC - HAR

syndactyly ( J:211773 )

IMPC - HAR

short tibia ( J:211773 )

♀

IMPC - HAR

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - HAR

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - HAR

skeleton

abnormal cranium morphology ( J:211773 )

IMPC - HAR

abnormal maxilla morphology ( J:211773 )

IMPC - HAR

short tibia ( J:211773 )

♀

IMPC - HAR

abnormal pelvic girdle bone morphology ( J:211773 )

♀

IMPC - HAR

vision/eye

impaired pupillary reflex ( J:211773 )

♀

IMPC - HAR

abnormal optic disk morphology ( J:211773 )

IMPC - HAR

mydriasis ( J:211773 )

♀

IMPC - HAR

narrow eye opening ( J:211773 )

♀

IMPC - HAR

abnormal retina morphology ( J:211773 )

♂

IMPC - HAR

abnormal retina vasculature morphology ( J:211773 )

♂

IMPC - HAR

abnormal retina blood vessel morphology ( J:211773 )

♀

IMPC - HAR

Genotype
MGI:5797827

ht2

• Allelic Composition: Smoc1^{tm1b(EUCOMM)Wtsi}/Smoc1⁺
• Genetic Background: C57BL/6N-Smoc1^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0348_1_C03

Data Sources

IMPC Data for Smoc1

cardiovascular system

increased heart weight ( J:211773 )

♂

IMPC - HAR

craniofacial

abnormal maxilla morphology ( J:211773 )

IMPC - HAR

growth/size/body

increased heart weight ( J:211773 )

♂

IMPC - HAR

abnormal maxilla morphology ( J:211773 )

IMPC - HAR

hematopoietic system

increased basophil cell number ( J:211773 )

IMPC - HAR

decreased erythrocyte cell number ( J:211773 )

IMPC - HAR

increased red blood cell distribution width ( J:211773 )

IMPC - HAR

increased neutrophil cell number ( J:211773 )

♂

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - HAR

increased large unstained cell number ( J:211773 )

♀

IMPC - HAR

homeostasis/metabolism

decreased circulating iron level ( J:211773 )

♂

IMPC - HAR

immune system

increased basophil cell number ( J:211773 )

IMPC - HAR

increased neutrophil cell number ( J:211773 )

♂

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - HAR

increased large unstained cell number ( J:211773 )

♀

IMPC - HAR

skeleton

abnormal maxilla morphology ( J:211773 )

IMPC - HAR

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HAR