Phenotypes associated with this allele

• Allele Symbol: Bbs5^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548622
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bbs5^tm1b(EUCOMM)Wtsi/Bbs5^tm1b(EUCOMM)Wtsi	C57BL/6NTac-Bbs5^tm1b(EUCOMM)Wtsi/H	MGI:5756790

Genotype
MGI:5756790

hm1

• Allelic Composition: Bbs5^{tm1b(EUCOMM)Wtsi}/Bbs5^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6NTac-Bbs5^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0227_3_C06

Data Sources

IMPC Data for Bbs5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - HAR

behavior/neurological

tremors ( J:211773 )

♂

IMPC - HAR

decreased grip strength ( J:211773 )

♀

IMPC - HAR

abnormal gait ( J:211773 )

♂

IMPC - HAR

cardiovascular system

decreased heart weight ( J:211773 )

IMPC - HAR

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - HAR

hematopoietic system

increased hematocrit ( J:211773 )

♀

IMPC - HAR

increased hemoglobin content ( J:211773 )

IMPC - HAR

increased mean corpuscular hemoglobin ( J:211773 )

IMPC - HAR

increased mean corpuscular volume ( J:211773 )

♀

IMPC - HAR

thrombocytopenia ( J:211773 )

♂

IMPC - HAR

increased lymphocyte cell number ( J:211773 )

IMPC - HAR

increased monocyte cell number ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased circulating fructosamine level ( J:211773 )

♂

IMPC - HAR

increased circulating glucose level ( J:211773 )

IMPC - HAR

increased fasting circulating glucose level ( J:211773 )

IMPC - HAR

decreased circulating triglyceride level ( J:211773 )

♀

IMPC - HAR

increased circulating alanine transaminase level ( J:211773 )

IMPC - HAR

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - HAR

increased circulating aspartate transaminase level ( J:211773 )

IMPC - HAR

decreased respiratory quotient ( J:211773 )

♂

IMPC - HAR

impaired glucose tolerance ( J:211773 )

IMPC - HAR

immune system

increased lymphocyte cell number ( J:211773 )

IMPC - HAR

increased monocyte cell number ( J:211773 )

IMPC - HAR

limbs/digits/tail

short tibia ( J:211773 )

IMPC - HAR

nervous system

decreased dendritic spine density ( J:279506 )

• 32% reduction in overall spine density of dentate gyrus neurons at P21

decreased dendritic spine length ( J:279506 )

• 34% reduction in dentate gyrus neuron dendritic length at P21

skeleton

short tibia ( J:211773 )

IMPC - HAR

abnormal bone structure ( J:211773 )

♀

IMPC - HAR

decreased bone mineral content ( J:211773 )

IMPC - HAR

decreased bone mineral density ( J:211773 )

IMPC - HAR

vision/eye

abnormal retina morphology ( J:211773 )

♂

IMPC - HAR