Phenotypes associated with this allele

• Allele Symbol: Dyrk1b^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548430
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dyrk1b^tm1b(EUCOMM)Wtsi/Dyrk1b^tm1b(EUCOMM)Wtsi	C57BL/6N-Dyrk1b^tm1b(EUCOMM)Wtsi/Ics	MGI:6262332
ht2	Dyrk1b^tm1b(EUCOMM)Wtsi/Dyrk1b^+	C57BL/6N-Dyrk1b^tm1b(EUCOMM)Wtsi/Ics	MGI:5797494

Genotype
MGI:6262332

hm1

• Allelic Composition: Dyrk1b^{tm1b(EUCOMM)Wtsi}/Dyrk1b^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Dyrk1b^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0775_3_H05

Data Sources

IMPC Data for Dyrk1b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - ICS

Genotype
MGI:5797494

ht2

• Allelic Composition: Dyrk1b^{tm1b(EUCOMM)Wtsi}/Dyrk1b⁺
• Genetic Background: C57BL/6N-Dyrk1b^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0775_3_H05

Data Sources

IMPC Data for Dyrk1b

behavior/neurological

decreased startle reflex ( J:211773 )

♂

IMPC - ICS

decreased locomotor activity ( J:211773 )

IMPC - ICS

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - ICS

hematopoietic system

decreased lymphocyte cell number ( J:211773 )

IMPC - ICS

decreased large unstained cell number ( J:211773 )

IMPC - ICS

homeostasis/metabolism

decreased blood urea nitrogen level ( J:211773 )

IMPC - ICS

immune system

decreased lymphocyte cell number ( J:211773 )

IMPC - ICS

decreased large unstained cell number ( J:211773 )

IMPC - ICS

nervous system

increased prepulse inhibition ( J:211773 )

IMPC - ICS

skeleton

decreased bone mineral density ( J:211773 )

♂

IMPC - ICS

vision/eye

abnormal retina morphology ( J:211773 )

IMPC - ICS

abnormal retina inner nuclear layer morphology ( J:211773 )

♀

IMPC - ICS

decreased total retina thickness ( J:211773 )

IMPC - ICS