Phenotypes associated with this allele

• Allele Symbol: Cdk8^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5548408
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk8^tm1b(EUCOMM)Hmgu/Cdk8^tm1b(EUCOMM)Hmgu	C57BL/6N-Cdk8^tm1b(EUCOMM)Hmgu/Ics	MGI:5756855
ht2	Cdk8^tm1b(EUCOMM)Hmgu/Cdk8^+	C57BL/6N-Cdk8^tm1b(EUCOMM)Hmgu/Ics	MGI:6771956

Genotype
MGI:5756855

hm1

• Allelic Composition: Cdk8^{tm1b(EUCOMM)Hmgu}/Cdk8^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Cdk8^{tm1b(EUCOMM)Hmgu}/Ics
• Cell Lines: HEPD0681_5_A08

Data Sources

IMPC Data for Cdk8

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:211773 )

IMPC - ICS

embryo

abnormal embryo turning ( J:211773 )

IMPC - ICS

abnormal embryo size ( J:211773 )

IMPC - ICS

abnormal neural tube closure ( J:211773 )

IMPC - ICS

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - ICS

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - ICS

nervous system

abnormal neural tube closure ( J:211773 )

IMPC - ICS

Genotype
MGI:6771956

ht2

• Allelic Composition: Cdk8^{tm1b(EUCOMM)Hmgu}/Cdk8⁺
• Genetic Background: C57BL/6N-Cdk8^{tm1b(EUCOMM)Hmgu}/Ics
• Cell Lines: HEPD0681_5_A08

Data Sources

IMPC Data for Cdk8

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - ICS

abnormal freezing behavior ( J:211773 )

IMPC - ICS