Phenotypes associated with this allele

• Allele Symbol: Nxn^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548389
• Summary: 20 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nxn^tm1b(EUCOMM)Wtsi/Nxn^tm1b(EUCOMM)Wtsi	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Bay	MGI:5757450
hm2	Nxn^tm1b(EUCOMM)Wtsi/Nxn^tm1b(EUCOMM)Wtsi	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Ccpcz	MGI:6480536
hm3	Nxn^tm1b(EUCOMM)Wtsi/Nxn^tm1b(EUCOMM)Wtsi	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/H	MGI:5757453
hm4	Nxn^tm1b(EUCOMM)Wtsi/Nxn^tm1b(EUCOMM)Wtsi	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Ics	MGI:5757452
hm5	Nxn^tm1b(EUCOMM)Wtsi/Nxn^tm1b(EUCOMM)Wtsi	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Ieg	MGI:5757451
hm6	Nxn^tm1b(EUCOMM)Wtsi/Nxn^tm1b(EUCOMM)Wtsi	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/J	MGI:5757448
hm7	Nxn^tm1b(EUCOMM)Wtsi/Nxn^tm1b(EUCOMM)Wtsi	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/MbpMmucd	MGI:6394343
hm8	Nxn^tm1b(EUCOMM)Wtsi/Nxn^tm1b(EUCOMM)Wtsi	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Nju	MGI:5757454
hm9	Nxn^tm1b(EUCOMM)Wtsi/Nxn^tm1b(EUCOMM)Wtsi	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Rbrc	MGI:5757455
hm10	Nxn^tm1b(EUCOMM)Wtsi/Nxn^tm1b(EUCOMM)Wtsi	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Ucd	MGI:5757449
hm11	Nxn^tm1b(EUCOMM)Wtsi/Nxn^tm1b(EUCOMM)Wtsi	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5757456
ht12	Nxn^tm1b(EUCOMM)Wtsi/Nxn^+	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Bay	MGI:5608339
ht13	Nxn^tm1b(EUCOMM)Wtsi/Nxn^+	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Ccpcz	MGI:6461492
ht14	Nxn^tm1b(EUCOMM)Wtsi/Nxn^+	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/H	MGI:5757444
ht15	Nxn^tm1b(EUCOMM)Wtsi/Nxn^+	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Ics	MGI:6263066
ht16	Nxn^tm1b(EUCOMM)Wtsi/Nxn^+	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/MbpMmucd	MGI:6325161
ht17	Nxn^tm1b(EUCOMM)Wtsi/Nxn^+	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Nju	MGI:6263067
ht18	Nxn^tm1b(EUCOMM)Wtsi/Nxn^+	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Rbrc	MGI:5757447
ht19	Nxn^tm1b(EUCOMM)Wtsi/Nxn^+	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Ucd	MGI:5757446
ht20	Nxn^tm1b(EUCOMM)Wtsi/Nxn^+	C57BL/6N-Nxn^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5757443

Genotype
MGI:5757450

hm1

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0045_1_A11

Data Sources

IMPC Data for Nxn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

unresponsive to tactile stimuli ( J:211773 )

IMPC - BCM

craniofacial

abnormal facial morphology ( J:211773 )

IMPC - BCM

cleft palate ( J:211773 )

IMPC - BCM

facial cleft ( J:211773 )

IMPC - BCM

abnormal head shape ( J:211773 )

IMPC - BCM

digestive/alimentary system

cleft palate ( J:211773 )

IMPC - BCM

embryo

abnormal embryo size ( J:211773 )

IMPC - BCM

growth/size/body

abnormal facial morphology ( J:211773 )

IMPC - BCM

cleft palate ( J:211773 )

IMPC - BCM

facial cleft ( J:211773 )

IMPC - BCM

abnormal head shape ( J:211773 )

IMPC - BCM

abnormal embryo size ( J:211773 )

IMPC - BCM

abnormal head size ( J:211773 )

IMPC - BCM

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

Genotype
MGI:6480536

hm2

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Ccpcz
• Cell Lines: EPD0045_1_B11

Data Sources

IMPC Data for Nxn

behavior/neurological

no spontaneous movement ( J:211773 )

IMPC - CCP-IMG

craniofacial

abnormal facial morphology ( J:211773 )

IMPC - CCP-IMG

abnormal head shape ( J:211773 )

IMPC - CCP-IMG

growth/size/body

abnormal facial morphology ( J:211773 )

IMPC - CCP-IMG

abnormal head shape ( J:211773 )

IMPC - CCP-IMG

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - CCP-IMG

Genotype
MGI:5757453

hm3

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0045_1_B11

Data Sources

IMPC Data for Nxn

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:5757452

hm4

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0045_1_B11

Data Sources

IMPC Data for Nxn

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - ICS

Genotype
MGI:5757451

hm5

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0045_1_B11

Data Sources

IMPC Data for Nxn

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:5757448

hm6

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/J
• Cell Lines: EPD0045_1_A11

Data Sources

IMPC Data for Nxn

craniofacial

abnormal craniofacial morphology ( J:211773 )

IMPC - JAX

abnormal facial morphology ( J:211773 )

IMPC - JAX

cleft palate ( J:211773 )

IMPC - JAX

digestive/alimentary system

cleft palate ( J:211773 )

IMPC - JAX

embryo

abnormal embryo size ( J:211773 )

IMPC - JAX

growth/size/body

abnormal facial morphology ( J:211773 )

IMPC - JAX

cleft palate ( J:211773 )

IMPC - JAX

abnormal embryo size ( J:211773 )

IMPC - JAX

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6394343

hm7

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/MbpMmucd
• Cell Lines: EPD0045_1_A11

Data Sources

IMPC Data for Nxn

growth/size/body

microcephaly ( J:211773 )

IMPC - UCD

limbs/digits/tail

syndactyly ( J:211773 )

IMPC - UCD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:5757454

hm8

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Nju
• Cell Lines: EPD0045_1_A11

Data Sources

IMPC Data for Nxn

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - MARC

Genotype
MGI:5757455

hm9

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Rbrc
• Cell Lines: EPD0045_1_A11

Data Sources

IMPC Data for Nxn

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - RBRC

Genotype
MGI:5757449

hm10

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Ucd
• Cell Lines: EPD0045_1_A11

Data Sources

IMPC Data for Nxn

craniofacial

abnormal craniofacial morphology ( J:211773 )

IMPC - TCP

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - TCP

Genotype
MGI:5757456

hm11

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0045_1_B11

Data Sources

IMPC Data for Nxn

cardiovascular system

absent stapedial artery ( J:239583 )

DMDD

dilated liver sinusoidal space ( J:239583 )

DMDD

abnormal vitelline vein topology ( J:239583 )

DMDD

double outlet right ventricle ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

craniofacial

cleft palate ( J:239583 )

DMDD

digestive/alimentary system

cleft palate ( J:239583 )

DMDD

decreased intestine length ( J:239583 )

DMDD

embryo

abnormal vitelline vein topology ( J:239583 )

DMDD

abnormal Mullerian duct morphology ( J:239583 )

DMDD

growth/size/body

cleft palate ( J:239583 )

DMDD

hearing/vestibular/ear

absent stapedial artery ( J:239583 )

DMDD

liver/biliary system

dilated liver sinusoidal space ( J:239583 )

DMDD

herniated liver ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:5608339

ht12

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn⁺
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0045_1_A11

Data Sources

IMPC Data for Nxn

behavior/neurological

unresponsive to tactile stimuli ( J:211773 )

IMPC - BCM

Genotype
MGI:6461492

ht13

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn⁺
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Ccpcz
• Cell Lines: EPD0045_1_B11

Data Sources

IMPC Data for Nxn

endocrine/exocrine glands

abnormal mammary gland morphology ( J:211773 )

♂

IMPC - CCP-IMG

hematopoietic system

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - CCP-IMG

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - CCP-IMG

increased circulating triglyceride level ( J:211773 )

♂

IMPC - CCP-IMG

immune system

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - CCP-IMG

integument

abnormal mammary gland morphology ( J:211773 )

♂

IMPC - CCP-IMG

Genotype
MGI:5757444

ht14

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn⁺
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0045_1_B11

Data Sources

IMPC Data for Nxn

craniofacial

abnormal snout morphology ( J:211773 )

♀

IMPC - HAR

growth/size/body

abnormal snout morphology ( J:211773 )

♀

IMPC - HAR

Genotype
MGI:6263066

ht15

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn⁺
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0045_1_B11

Data Sources

IMPC Data for Nxn

behavior/neurological

decreased exploration in new environment ( J:211773 )

♀

IMPC - ICS

abnormal freezing behavior ( J:211773 )

♀

IMPC - ICS

abnormal locomotor behavior ( J:211773 )

♀

IMPC - ICS

decreased locomotor activity ( J:211773 )

♀

IMPC - ICS

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - ICS

limbs/digits/tail

abnormal digit morphology ( J:211773 )

IMPC - ICS

Genotype
MGI:6325161

ht16

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn⁺
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/MbpMmucd
• Cell Lines: EPD0045_1_A11

Data Sources

IMPC Data for Nxn

growth/size/body

microcephaly ( J:211773 )

IMPC - UCD

limbs/digits/tail

syndactyly ( J:211773 )

IMPC - UCD

short tibia ( J:211773 )

♂

IMPC - UCD

skeleton

short tibia ( J:211773 )

♂

IMPC - UCD

Genotype
MGI:6263067

ht17

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn⁺
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Nju
• Cell Lines: EPD0045_1_A11

Data Sources

IMPC Data for Nxn

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - MARC

vision/eye

abnormal optic disk morphology ( J:211773 )

IMPC - MARC

Genotype
MGI:5757447

ht18

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn⁺
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Rbrc
• Cell Lines: EPD0045_1_A11

Data Sources

IMPC Data for Nxn

limbs/digits/tail

short tibia ( J:211773 )

♂

IMPC - RBRC

skeleton

short tibia ( J:211773 )

♂

IMPC - RBRC

Genotype
MGI:5757446

ht19

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn⁺
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Ucd
• Cell Lines: EPD0045_1_A11

Data Sources

IMPC Data for Nxn

endocrine/exocrine glands

small adrenal glands ( J:211773 )

♂

IMPC - TCP

Genotype
MGI:5757443

ht20

• Allelic Composition: Nxn^{tm1b(EUCOMM)Wtsi}/Nxn⁺
• Genetic Background: C57BL/6N-Nxn^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0045_1_B11

Data Sources

IMPC Data for Nxn

craniofacial

abnormal cranium morphology ( J:211773 )

♀

IMPC - WTSI

abnormal snout morphology ( J:211773 )

♀

IMPC - WTSI

growth/size/body

abnormal snout morphology ( J:211773 )

♀

IMPC - WTSI

skeleton

abnormal cranium morphology ( J:211773 )

♀

IMPC - WTSI

vision/eye

abnormal eyelid morphology ( J:211773 )

♀

IMPC - WTSI