Phenotypes associated with this allele

• Allele Symbol: Sema4a^tm3.1Akum
• Allele Name: targeted mutation 3.1, Atsushi Kumanogoh
• Allele ID: MGI:5548203
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sema4a^tm3.1Akum/Sema4a^tm3.1Akum	involves: C57BL/6J	MGI:5548216
ht2	Sema4a^tm2.1Akum/Sema4a^tm3.1Akum	involves: C57BL/6J	MGI:5548215

Genotype
MGI:5548216

hm1

• Allelic Composition: Sema4a^tm3.1Akum/Sema4a^tm3.1Akum
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased retina apoptosis ( J:205754 )

• increased in the outer nuclear layer

decreased retina photoreceptor cell number ( J:205754 )

• complete loss by 4 weeks

abnormal photoreceptor outer segment morphology ( J:205754 )

• severely disrupted at 2 weeks

absent photoreceptor outer segment ( J:205754 )

• at 4 weeks

abnormal retina pigment epithelium morphology ( J:205754 )

• impaired endosomal sorting function

retina degeneration ( J:205754 )

• however, gene transfer with the wild-type sequence prevents retinal degeneration

cellular

increased retina apoptosis ( J:205754 )

• increased in the outer nuclear layer

nervous system

decreased retina photoreceptor cell number ( J:205754 )

• complete loss by 4 weeks

abnormal photoreceptor outer segment morphology ( J:205754 )

• severely disrupted at 2 weeks

absent photoreceptor outer segment ( J:205754 )

• at 4 weeks

pigmentation

abnormal retina pigment epithelium morphology ( J:205754 )

• impaired endosomal sorting function

Genotype
MGI:5548215

ht2

• Allelic Composition: Sema4a^tm2.1Akum/Sema4a^tm3.1Akum
• Genetic Background: involves: C57BL/6J

vision/eye

vision/eye phenotype ( J:205754 )

N • mice exhibit normal retina morphology