All Phenotypes Ctdnep1<tm3Ryn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ctdnep1^tm3Ryn
targeted mutation 3, Ryuichi Nishinakamura
MGI:5548188

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctdnep1^tm3Ryn/Ctdnep1^tm3Ryn Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺	involves: 129 * C57BL/6 * C57BL/6J	MGI:5548192
cn2	Ctdnep1^tm3Ryn/Ctdnep1^tm3Ryn Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺	involves: 129X1/SvJ * C57BL/6 * C57BL/6J	MGI:5548193
cn3	Ctdnep1^tm3Ryn/Ctdnep1^tm3Ryn Tg(Hoxb7-cre)13Amc/0	involves: C57BL/6	MGI:5548191

Allelic Composition	Ctdnep1^tm3Ryn/Ctdnep1^tm3Ryn Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctdnep1^tm3Ryn mutation (0 available); any Ctdnep1 mutation (20 available)
Six2^{tm1(tTA,tetO-EGFP/cre)Amc} mutation (0 available); any Six2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:205755 )

• mice begin to die after weaning with all mice dying before 8 weeks of age and a median survival of 33.3 days

renal/urinary system

abnormal kidney morphology ( J:205755 )

• a cavity appears at P14 and expands with age

• however, BMP inhibition rescues kidney defects

small kidney ( J:205755 )

• at P28

decreased kidney weight ( J:205755 )

abnormal nephron morphology ( J:205755 )

• progressive loss of nephron components, including glomeruli, proximal and distal tubules, and the loop of Henle located in the cortex and outer medullary regions

renal glomerulus atrophy ( J:205755 )

• fewer glomeruli at P7 and P14

abnormal proximal convoluted tubule morphology ( J:205755 )

• reduced number of tubules at P21

Allelic Composition	Ctdnep1^tm3Ryn/Ctdnep1^tm3Ryn Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctdnep1^tm3Ryn mutation (0 available); any Ctdnep1 mutation (20 available)
Gt(ROSA)26Sor^tm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (944 available)
Six2^{tm1(tTA,tetO-EGFP/cre)Amc} mutation (0 available); any Six2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

decreased kidney apoptosis ( J:205755 )

• apoptotic cells in the nephron as early as P7

cellular

decreased kidney apoptosis ( J:205755 )

• apoptotic cells in the nephron as early as P7

Allelic Composition	Ctdnep1^tm3Ryn/Ctdnep1^tm3Ryn Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctdnep1^tm3Ryn mutation (0 available); any Ctdnep1 mutation (20 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:205755 )

N	• mice are obtained at a Mendelian frequency and survive over 1 year

renal/urinary system

renal/urinary system phenotype ( J:205755 )

N	• mice exhibit normal kidneys

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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