About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdgfatm2Cbet
targeted mutation 2, Christer Betsholtz
MGI:5548172
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pdgfatm2Cbet/Pdgfatm2Cbet involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5548176
cx2
 		Pdgfatm2Cbet/Pdgfatm2Cbet
Pdgfctm1Nagy/Pdgfctm1Nagy 		B6.129-Pdgfctm1Nagy Pdgfatm2Cbet MGI:5548180
cx3
 		Pdgfatm1Cbet/Pdgfatm2Cbet
Pdgfratm11(EGFP)Sor/Pdgfra+ 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 MGI:5548177
cx4
 		Pdgfatm2Cbet/Pdgfatm2Cbet
Pdgfctm1Nagy/Pdgfctm1Nagy 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5548178


Genotype
MGI:5548176
hm1
Allelic
Composition		 Pdgfatm2Cbet/Pdgfatm2Cbet
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfatm2Cbet mutation (1 available); any Pdgfa mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:205009 )
N
• unlike Pdgfatm1Cbet homozygotes, mice survive to adulthood

respiratory system
respiratory system phenotype ( J:205009 )
N
• mice exhibit normal lung morphology




Genotype
MGI:5548180
cx2
Allelic
Composition		 Pdgfatm2Cbet/Pdgfatm2Cbet
Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic
Background		 B6.129-Pdgfctm1Nagy Pdgfatm2Cbet
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfatm2Cbet mutation (1 available); any Pdgfa mutation (21 available)
Pdgfctm1Nagy mutation (0 available); any Pdgfc mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
spina bifida ( J:205009 )
• in all mice, but heterogeneity in severity
spina bifida occulta ( J:205009 )
• in 2 of 5 mice

nervous system
spina bifida ( J:205009 )
• in all mice, but heterogeneity in severity
spina bifida occulta ( J:205009 )
• in 2 of 5 mice

skeleton
spina bifida occulta ( J:205009 )
• in 2 of 5 mice




Genotype
MGI:5548177
cx3
Allelic
Composition		 Pdgfatm1Cbet/Pdgfatm2Cbet
Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfatm1Cbet mutation (0 available); any Pdgfa mutation (21 available)
Pdgfatm2Cbet mutation (1 available); any Pdgfa mutation (21 available)
Pdgfratm11(EGFP)Sor mutation (1 available); any Pdgfra mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal lung morphology ( J:205009 )
• progressive dilated distal airway
emphysema ( J:205009 )
• at 3 months

digestive/alimentary system
digestive/alimentary phenotype ( J:205009 )
N
• mice exhibit normal gastrointestinal tract

renal/urinary system
renal/urinary system phenotype ( J:205009 )
N
• mice exhibit normal kidneys

skeleton
skeleton phenotype ( J:205009 )
N
• mice exhibit normal skeleton




Genotype
MGI:5548178
cx4
Allelic
Composition		 Pdgfatm2Cbet/Pdgfatm2Cbet
Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfatm2Cbet mutation (1 available); any Pdgfa mutation (21 available)
Pdgfctm1Nagy mutation (0 available); any Pdgfc mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
spina bifida ( J:205009 )
• in all mice
spina bifida occulta ( J:205009 )
• in some mice

digestive/alimentary system
abnormal small intestine morphology ( J:205009 )
• reduced thickness of the submucosal mesenchyme in the upper small intestine
decreased small intestinal villus number ( J:205009 )
• reduced number of villi in the upper small intestine

growth/size/body
decreased body size ( J:205009 )

skeleton
spina bifida occulta ( J:205009 )
• in some mice
kyphosis ( J:205009 )
• severe kyphosis of the thoracic spine in 3 of 11 mice

embryo
spina bifida ( J:205009 )
• in all mice
spina bifida occulta ( J:205009 )
• in some mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory