Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pdgfatm1Cbet
Name:	platelet derived growth factor, alpha; targeted mutation 1, Christer Betsholtz
MGI ID:	MGI:1926817
Synonyms:	PDGF-A (-)
Gene:	Pdgfa  Location: Chr5:138961769-138983125 bp, - strand  Genetic Position: Chr5, 77.65 cM
Alliance:	Pdgfatm1Cbet page

Germline Transmission:	Earliest citation of germline transmission: J:33629
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of exon 4 of Pdgfa gene, which encodes the N-terminal half of the mature Pdgfa chain, with a neomycin cassette. (J:33629)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	58 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfa Mutation:	19 strains or lines available

Original:	J:33629 Bostrom H, et al., PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell. 1996 Jun 14;85(6):863-73
All:	17 reference(s)