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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nr4a1tm1Pcn
targeted mutation 1, Pierre Chambon
MGI:5546594
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nr4a1tm1Pcn/Nr4a1tm1Pcn
Tg(Cr2-cre)3Cgn/0 		involves: 129 MGI:6717462
cn2
 		Cd79atm1(cre)Reth/Cd79a+
Nr4a1tm1Pcn/Nr4a1tm1Pcn 		involves: 129 * BALB/c MGI:6717461
cn3
 		Cd79atm1(cre)Reth/Cd79a+
Nr4a1tm1Pcn/Nr4a1tm1Pcn
Nr4a3em1Juz/Nr4a3em1Juz 		involves: 129 * BALB/c * C57BL/6 MGI:6717460
cn4
 		Nr4a1tm1Pcn/Nr4a1tm1Pcn
Foxp3tm4(YFP/icre)Ayr/Foxp3+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5546602


Genotype
MGI:6717462
cn1
Allelic
Composition		 Nr4a1tm1Pcn/Nr4a1tm1Pcn
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a1tm1Pcn mutation (0 available); any Nr4a1 mutation (39 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased B cell proliferation ( J:306652 )
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

hematopoietic system
increased B cell proliferation ( J:306652 )
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

immune system
increased B cell proliferation ( J:306652 )
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)




Genotype
MGI:6717461
cn2
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Nr4a1tm1Pcn/Nr4a1tm1Pcn
Genetic
Background		 involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
Nr4a1tm1Pcn mutation (0 available); any Nr4a1 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased B cell proliferation ( J:306652 )
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

hematopoietic system
increased B cell proliferation ( J:306652 )
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

immune system
increased B cell proliferation ( J:306652 )
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)




Genotype
MGI:6717460
cn3
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Nr4a1tm1Pcn/Nr4a1tm1Pcn
Nr4a3em1Juz/Nr4a3em1Juz
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
Nr4a1tm1Pcn mutation (0 available); any Nr4a1 mutation (39 available)
Nr4a3em1Juz mutation (0 available); any Nr4a3 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased B cell apoptosis ( J:306652 )
• greater survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)
increased B cell proliferation ( J:306652 )
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)

hematopoietic system
decreased B cell apoptosis ( J:306652 )
• greater survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)
increased B cell proliferation ( J:306652 )
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)

immune system
immune system phenotype ( J:306652 )
N
• normal T cell and B cell development and homeostasis
decreased B cell apoptosis ( J:306652 )
• greater survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)
increased B cell proliferation ( J:306652 )
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)




Genotype
MGI:5546602
cn4
Allelic
Composition		 Nr4a1tm1Pcn/Nr4a1tm1Pcn
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (55 available)
Nr4a1tm1Pcn mutation (0 available); any Nr4a1 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:205658 )
N
• the ratio of YFP+/YFP- regulatory T cells is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory