Phenotypes associated with this allele

• Allele Symbol: Trpm7^tm1Agry
• Allele Name: targeted mutation 1, Alexey G Ryazanov
• Allele ID: MGI:5546500
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpm7^tm1Agry/Trpm7^tm1Agry	involves: 129	MGI:5546511
ht2	Trpm7^tm1Agry/Trpm7^+	involves: 129	MGI:5546512

Genotype
MGI:5546511

hm1

• Allelic Composition: Trpm7^tm1Agry/Trpm7^tm1Agry
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:205665 )

• no mice are born

embryo

embryonic growth arrest ( J:205665 )

• arrest after a full day of gastrulation

decreased embryo size ( J:205665 )

• at E7.5

cellular

abnormal cell physiology ( J:205665 )

• ES cells do not grow significantly in control media

• however, supplemental magnesium rescues growth

growth/size/body

decreased embryo size ( J:205665 )

• at E7.5

Genotype
MGI:5546512

ht2

• Allelic Composition: Trpm7^tm1Agry/Trpm7⁺
• Genetic Background: involves: 129

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:205665 )

• when maintained on a magnesium deficient diet

homeostasis/metabolism

abnormal magnesium ion homeostasis ( J:205665 )

• decreased in the serum, urine and bone when maintained on a diet with 0.17% magnesium

• decreased in the bone when maintained on a normal diet

• decreased in the plasma, erythrocyte and bone when maintained on a magnesium deficient diet

• however, mice maintained on a normal diet exhibit normal serum and erythrocyte magnesium concentration

decreased circulating magnesium level ( J:205665 )

• when maintained on a diet with 0.17% magnesium

• however, mice maintained on a normal diet exhibit normal serum magnesium concentration

decreased erythrocyte magnesium level ( J:205665 )

• when maintained on a magnesium deficient diet

• however, mice maintained on a normal diet exhibit normal erythrocyte magnesium concentration

decreased urine magnesium level ( J:205665 )

• when maintained on a diet with 0.17% magnesium

behavior/neurological

limb grasping ( J:205665 )

• severe in 6 of 10 mice when maintained on a magnesium deficient diet

tremors ( J:205665 )

• with slow movement and violent sudden leaps in response to light and noise in 2 of 10 mice when maintained on a magnesium deficient diet

seizures ( J:205665 )

• in 3 of 10 mice when maintained on a magnesium deficient diet

digestive/alimentary system

abnormal digestion ( J:205665 )

• increased fecal magnesium indicates decreased intestinal magnesium absorption

nervous system

seizures ( J:205665 )

• in 3 of 10 mice when maintained on a magnesium deficient diet

abnormal channel response ( J:205665 )

• mice exhibit reduced Trpm channel activity and increased sensitivity to magnesium inhibition compared with wild-type mice

renal/urinary system

decreased urine magnesium level ( J:205665 )

• when maintained on a diet with 0.17% magnesium

immune system

increased susceptibility to type IV hypersensitivity reaction ( J:205665 )

• in oxazolone-treated mice on a control diet

• however, placement on a magnesium supplemented diet slightly lowers response as in wild-type mice

hematopoietic system

decreased erythrocyte magnesium level ( J:205665 )

• when maintained on a magnesium deficient diet

• however, mice maintained on a normal diet exhibit normal erythrocyte magnesium concentration