mortality/aging
|
N |
• born at expected Mendelian ratio
(J:170814)
|
growth/size/body
|
N |
• indistinguishable body mass compared to control animals (heterozygous for the Casp8 allele and homozygous for the Ripk3) between days 20 to 160
|
|
|
• at 15 weeks of age
(J:170814)
• from 2 to 8 months
(J:170815)
• high levels of CD3+ T cells and CD19+ B cells contribute to greater number of leukocytes in spleen
(J:170815)
|
cellular
|
|
• resistant to CD95-activated apoptosis in thymocytes
|
|
|
• resistant to Fas-activated cell death
|
|
|
• comparing to control animals upon stimulation by pro-hepatocyte apoptosis agent (anti-CD95 antibody)
|
liver/biliary system
|
|
• resistant to TNF-dependent fatal liver hepatitis pathway
|
|
|
• comparing to control animals upon stimulation by pro-hepatocyte apoptosis agent (anti-CD95 antibody)
|
immune system
|
N |
• no evidence of skin inflammation at up to 6 months of age
|
|
|
• resistant to CD95-activated apoptosis in thymocytes
|
|
|
• at 15 weeks of age
(J:170814)
• from 2 to 8 months
(J:170815)
• high levels of CD3+ T cells and CD19+ B cells contribute to greater number of leukocytes in spleen
(J:170815)
|
|
|
• significantly greater numbers of leukocytes in secondary lymphoid tissues
|
|
|
• increase in the number of CD19+ B cells in secondary lymphoid tissues
|
|
|
• normal mature T-lymphocyte subsets in 1 month old mice, but show a marked increased in B220+, CD3+ cells with age
(J:170814)
• contributes to lymphadenopathy and splenomegaly
(J:170815)
• abnormal T cell accumulation following Fas death-receptor-induced death pathways activation due to the failure to response to both apoptosis and necroptosis
(J:170815)
• increase in the number of CD3+ T cells in secondary lymphoid tissues is the primary cause of increase the increase in the number leukocytes in these tissues
(J:170815)
|
|
|
• bone marrow derived macrophages are resistant to RIP3 dependent necroptosis
|
|
|
• resistant to Fas-activated cell death
|
|
|
• lymphadenopathy with more lymphoid cells in splenic white pulp
• enlarged cervical lymph node at 6 months and axial lymph node at 2 to 8 months of age
|
|
|
• enlarged axial lymph node at 2 to 8 months of age
|
|
|
• enlarged cervical lymph node at 6 months
|
|
|
• normal lymphoid organs comparing to control animals at 4 weeks but display progressive severe lymphoaccumulation at 15 weeks
|
|
|
• lymphocytic infiltrates in the salivary glands, pancreas and lamina propria of both the stomach and small intestine
|
hematopoietic system
|
N |
• T-lymphocyte proliferation and activation in response to immune challenge is comparable to control animals
(J:170814)
• CD11b+F4/80+ bone marrow-derived mononuclear production is not affected
(J:170815)
• myeloid and lymphocyte cell generation in bone marrow, spleen, thymus, and lymph node of DKO mice is unaffected compared to littermate controls
(J:170815)
• no defect in T-cell activation in response to antigen
(J:170815)
|
|
|
• resistant to CD95-activated apoptosis in thymocytes
|
|
|
• at 15 weeks of age
(J:170814)
• from 2 to 8 months
(J:170815)
• high levels of CD3+ T cells and CD19+ B cells contribute to greater number of leukocytes in spleen
(J:170815)
|
|
|
• significantly greater numbers of leukocytes in secondary lymphoid tissues
|
|
|
• increase in the number of CD19+ B cells in secondary lymphoid tissues
|
|
|
• normal mature T-lymphocyte subsets in 1 month old mice, but show a marked increased in B220+, CD3+ cells with age
(J:170814)
• contributes to lymphadenopathy and splenomegaly
(J:170815)
• abnormal T cell accumulation following Fas death-receptor-induced death pathways activation due to the failure to response to both apoptosis and necroptosis
(J:170815)
• increase in the number of CD3+ T cells in secondary lymphoid tissues is the primary cause of increase the increase in the number leukocytes in these tissues
(J:170815)
|
|
|
• bone marrow derived macrophages are resistant to RIP3 dependent necroptosis
|
|
|
• resistant to Fas-activated cell death
|
endocrine/exocrine glands
|
|
• resistant to CD95-activated apoptosis in thymocytes
|
Analysis Tools