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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cishtm1.1Cdon
targeted mutation 1.1, Chen Dong
MGI:5544426
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cishtm1.1Cdon/Cishtm1.1Cdon
Foxp3tm4(YFP/icre)Ayr/Foxp3+ 		involves: 129S/Sv * 129X1/SvJ * C57BL/6 MGI:5544440
cn2
 		Cishtm1.1Cdon/Cishtm1.1Cdon
Tg(Cd4-cre)1Cwi/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:5544439


Genotype
MGI:5544440
cn1
Allelic
Composition		 Cishtm1.1Cdon/Cishtm1.1Cdon
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background		 involves: 129S/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cishtm1.1Cdon mutation (0 available); any Cish mutation (22 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:204829 )
N
• mice exhibit normal asthmatic response




Genotype
MGI:5544439
cn2
Allelic
Composition		 Cishtm1.1Cdon/Cishtm1.1Cdon
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cishtm1.1Cdon mutation (0 available); any Cish mutation (22 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T-helper 2 cell differentiation ( J:204829 )
• enhanced Th2 response in an allergic asthma model, more so than in Cishtm1.2Cdon homozygotes
increased eosinophil cell number ( J:204829 )
• in the bronchoalveolar lavage fluid following induction of asthma
increased susceptibility to type I hypersensitivity reaction ( J:204829 )
• enhanced asthmatic response with more total cells and eosinophils in the bronchoalveolar lavage fluid
increased interleukin-10 secretion ( J:204829 )
• from Th2 cells in an allergic asthma model
increased interleukin-13 secretion ( J:204829 )
• from lung-associated lymph node cells and splenocytes re-stimulated ex vivo with ovalbumin
increased interleukin-4 secretion ( J:204829 )
• increased CD4+ IL4+ cells among lung infiltrates in a model of asthma
• from lung-associated lymph node cells and splenocytes re-stimulated ex vivo with ovalbumin
increased interleukin-5 secretion ( J:204829 )
• from lung-associated lymph node cells and splenocytes re-stimulated ex vivo with ovalbumin

hematopoietic system
abnormal T-helper 2 cell differentiation ( J:204829 )
• enhanced Th2 response in an allergic asthma model, more so than in Cishtm1.2Cdon homozygotes
increased eosinophil cell number ( J:204829 )
• in the bronchoalveolar lavage fluid following induction of asthma




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory