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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Capn6tm1Hiso
targeted mutation 1, Hiroyuki Sorimachi
MGI:5544425
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Capn6tm1Hiso/Capn6tm1Hiso B6.Cg-Capn6tm1Hiso MGI:5544429
ot2
Capn6tm1Hiso/Y B6.Cg-Capn6tm1Hiso MGI:5544430


Genotype
MGI:5544429
hm1
Allelic
Composition
Capn6tm1Hiso/Capn6tm1Hiso
Genetic
Background
B6.Cg-Capn6tm1Hiso
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn6tm1Hiso mutation (2 available); any Capn6 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Diameter of tongue muscle fibers is larger in Capn6tm1Hiso/Capn6tm1Hiso mice

muscle
• more advanced tube formation and development of striated structures at E16.5
• tongue muscle fiber diameter is increased relative to controls at E16.5
• degeneration is induced by cardiotoxin injection into the tibialis anterior, regeneration begins 4 days later
• more nuclei found in each regenerating myofiber of tibialis anterior muscle relative to heterozygous controls
• larger cross sectional area of each regenerating muscle

digestive/alimentary system
• more advanced tube formation and development of striated structures at E16.5
• tongue muscle fiber diameter is increased relative to controls at E16.5

craniofacial
• more advanced tube formation and development of striated structures at E16.5
• tongue muscle fiber diameter is increased relative to controls at E16.5

growth/size/body
• more advanced tube formation and development of striated structures at E16.5
• tongue muscle fiber diameter is increased relative to controls at E16.5




Genotype
MGI:5544430
ot2
Allelic
Composition
Capn6tm1Hiso/Y
Genetic
Background
B6.Cg-Capn6tm1Hiso
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn6tm1Hiso mutation (2 available); any Capn6 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• primary culture of skeletal muscle cells induced to differentiate into myotubules using horse serum have an increased number of nuclei relative to similarly treated control cells





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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory