All Phenotypes Capn6<tm1Hiso> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Capn6^tm1Hiso/Capn6^tm1Hiso	B6.Cg-Capn6^tm1Hiso	MGI:5544429
ot2	Capn6^tm1Hiso/Y	B6.Cg-Capn6^tm1Hiso	MGI:5544430

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Diameter of tongue muscle fibers is larger in Capn6^tm1Hiso/Capn6^tm1Hiso mice

muscle

abnormal tongue muscle morphology ( J:200747 )

• more advanced tube formation and development of striated structures at E16.5

• tongue muscle fiber diameter is increased relative to controls at E16.5

enhanced skeletal muscle regeneration ( J:200747 )

• degeneration is induced by cardiotoxin injection into the tibialis anterior, regeneration begins 4 days later

• more nuclei found in each regenerating myofiber of tibialis anterior muscle relative to heterozygous controls

• larger cross sectional area of each regenerating muscle

digestive/alimentary system

abnormal tongue muscle morphology ( J:200747 )

• more advanced tube formation and development of striated structures at E16.5

• tongue muscle fiber diameter is increased relative to controls at E16.5

craniofacial

abnormal tongue muscle morphology ( J:200747 )

• more advanced tube formation and development of striated structures at E16.5

• tongue muscle fiber diameter is increased relative to controls at E16.5

growth/size/body

abnormal tongue muscle morphology ( J:200747 )

• more advanced tube formation and development of striated structures at E16.5

• tongue muscle fiber diameter is increased relative to controls at E16.5

Allelic Composition	Capn6^tm1Hiso/Y
Genetic Background	B6.Cg-Capn6^tm1Hiso

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn6^tm1Hiso mutation (2 available); any Capn6 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal myogenesis ( J:200747 )

• primary culture of skeletal muscle cells induced to differentiate into myotubules using horse serum have an increased number of nuclei relative to similarly treated control cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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