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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Topbp1tm1.1Zqw
targeted mutation 1.1, Zhao-Qi Wang
MGI:5544423
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Topbp1tm1.1Zqw/Topbp1tm1.1Zqw involves: 129P2/OlaHsd * 129S4/SvJaeSor MGI:5544424


Genotype
MGI:5544424
hm1
Allelic
Composition		 Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Topbp1tm1.1Zqw mutation (0 available); any Topbp1 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Early embryonic developmental defects in Topbp1tm1.1Zqw/Topbp1tm1.1Zqw embryos

mortality/aging
embryonic lethality before implantation, complete penetrance ( J:200981 )
• based on failure of isolated E3.5 blastocysts to outgrow in culture

embryo
embryonic growth arrest ( J:200981 )
• blastocysts isolated at E3.5 fail to outgrow




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory