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| Caption | Inactivation of the ATR-Activation-Domain of Topbp1 results in early embryonic developmental defects in Topbp1tm1.1Zqw/Topbp1tm1.1Zqw embryos. (A) Decidua at E11.5 from intercrossing of heterozygous Topbp1tm1.1Zqw mice. Decidua in (I) was genotype Topbp1tm1.1Zqw/Topbp1+ (ki+). Decidua in (II) was empty, thus with unclear genotype. Bar= 1 mm. (B) Cultures of E3.5 blastocysts from heterozygous intercrosses. D1: 1 day after culture, D4: 4 days after culture. Arrows indicate inner cellmass (ICM). Bar = 50 micrometers. Genotypes are indicated on the top of respective images. Ki = knock-in; wt = wild-type. | ||||
| Copyright | This image is from Zhou ZW, PLoS Genet 2013 Aug;9(8):e1003702, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:200981 | ||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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