Phenotypes associated with this allele

• Allele Symbol: Nkx2-2^tm5.1Suss
• Allele Name: targeted mutation 5.1, Lori Sussel
• Allele ID: MGI:5544082
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx2-2^tm5.1Suss/Nkx2-2^tm5.1Suss	involves: 129S6/SvEvTac * C57BL/6J	MGI:5544100
cn2	Nkx2-2^tm5.1Suss/Nkx2-2^tm5.1Suss Tg(Pdx1-cre)6Tuv/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * NTac:NIHBS * SJL	MGI:5544101

Genotype
MGI:5544100

hm1

• Allelic Composition: Nkx2-2^tm5.1Suss/Nkx2-2^tm5.1Suss
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:204869 )

N • mice exhibit normal breeding/fertility

growth/size/body

growth/size/body region phenotype ( J:204869 )

N • mice exhibit normal body weight

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:204869 )

N • mice exhibit normal glucose tolerance

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:204869 )

N • mice exhibit normal pancreas tissue including normal islet morphology

Genotype
MGI:5544101

cn2

• Allelic Composition: Nkx2-2^tm5.1Suss/Nkx2-2^tm5.1Suss; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * NTac:NIHBS * SJL

mortality/aging

postnatal lethality, complete penetrance ( J:204869 )

• mice die within the first week after birth

homeostasis/metabolism

increased circulating glucose level ( J:204869 )

• at P1

hyperglycemia ( J:204869 )

• severe

endocrine/exocrine glands

decreased pancreatic alpha cell number ( J:204869 )

decreased pancreatic beta cell number ( J:204869 )

increased pancreatic epsilon cell number ( J:204869 )