All Phenotypes H2-Ab1<b-tm1Wug> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

H2-Ab1^b-tm1Wug
targeted mutation 1, Gregory F Wu
MGI:5543894

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2-Ab1^b-tm1Wug/H2-Ab1^b-tm1Wug	involves: C57BL/6	MGI:5543896
cn2	H2-Ab1^b-tm1Wug/H2-Ab1^b-tm1Wug Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129S2/SvPas * C57BL/6	MGI:5543897

Allelic Composition	H2-Ab1^b-tm1Wug/H2-Ab1^b-tm1Wug
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1^b-tm1Wug mutation (1 available); any H2-Ab1 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

absent CD4-positive, alpha-beta T cells ( J:204951 )

abnormal B cell physiology ( J:204951 )

• B cells fail to prime MOG-specific 2D2 TCR transgenic CD4 T cell proliferation unlike wild-type cells

abnormal dendritic cell physiology ( J:204951 )

• bone marrow-derived dendritic cells fail to generate an antigen-specific response unlike wild-type cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:204951 )

• resistant in a passive or active model

hematopoietic system

absent CD4-positive, alpha-beta T cells ( J:204951 )

abnormal B cell physiology ( J:204951 )

• B cells fail to prime MOG-specific 2D2 TCR transgenic CD4 T cell proliferation unlike wild-type cells

Allelic Composition	H2-Ab1^b-tm1Wug/H2-Ab1^b-tm1Wug Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
H2-Ab1^b-tm1Wug mutation (1 available); any H2-Ab1 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:204951 )

N	• mice exhibit normal B cell development

abnormal B cell physiology ( J:204951 )

• B cells prime MOG-specific 2D2 TCR transgenic CD4 T cell proliferation to a lesser extent than wild-type cells

abnormal dendritic cell physiology ( J:204951 )

• bone marrow-derived dendritic cells fail to generate an antigen-specific response unlike wild-type cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:204951 )

• resistant in a passive or active model

hematopoietic system

abnormal B cell physiology ( J:204951 )

• B cells prime MOG-specific 2D2 TCR transgenic CD4 T cell proliferation to a lesser extent than wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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