All Phenotypes Cyp11b2<tm1.1(cre)Brlt> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cyp11b2^{tm1.1(cre)Brlt}
targeted mutation 1.1, David T Breault
MGI:5543601

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cyp11b2^{tm1.1(cre)Brlt}/Cyp11b2⁺ Nr5a1^tm2Klp/Nr5a1^tm2Klp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:5550087
cn2	Cyp11b2^{tm1.1(cre)Brlt}/Cyp11b2⁺ Nr0b1^tm1Lja/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5550088

Allelic Composition	Cyp11b2^{tm1.1(cre)Brlt}/Cyp11b2⁺ Nr5a1^tm2Klp/Nr5a1^tm2Klp
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp11b2^{tm1.1(cre)Brlt} mutation (0 available); any Cyp11b2 mutation (43 available)
Nr5a1^tm2Klp mutation (2 available); any Nr5a1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal adrenal gland zona glomerulosa morphology ( J:204614 )

• zone is disorganized with pleomorphic nuclei, whereas inner zona fasciculata appears normal in young and old mice

• cells in the zona granulosa dedifferentiated with Nr5a1 deletion

Allelic Composition	Cyp11b2^{tm1.1(cre)Brlt}/Cyp11b2⁺ Nr0b1^tm1Lja/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp11b2^{tm1.1(cre)Brlt} mutation (0 available); any Cyp11b2 mutation (43 available)
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (1046 available)
Nr0b1^tm1Lja mutation (2 available); any Nr0b1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:204614 )

N	• loss of Nr0b1 does not impact ability of zona glomerusa cells to contribute to the inner zona fasciculata even at 8 months of age; postnatal zonation and lineage conversion in the adrenal gland are normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24