All Phenotypes Cyp11b2<tm1.1(cre)Brlt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cyp11b2^{tm1.1(cre)Brlt}
targeted mutation 1.1, David T Breault
MGI:5543601

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cyp11b2^{tm1.1(cre)Brlt}/Cyp11b2⁺ Nr5a1^tm2Klp/Nr5a1^tm2Klp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:5550087
cn2	Cyp11b2^{tm1.1(cre)Brlt}/Cyp11b2⁺ Nr0b1^tm1Lja/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5550088

Allelic Composition	Cyp11b2^{tm1.1(cre)Brlt}/Cyp11b2⁺ Nr5a1^tm2Klp/Nr5a1^tm2Klp
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp11b2^{tm1.1(cre)Brlt} mutation (0 available); any Cyp11b2 mutation (40 available)
Nr5a1^tm2Klp mutation (2 available); any Nr5a1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal adrenal gland zona glomerulosa morphology ( J:204614 )

• zone is disorganized with pleomorphic nuclei, whereas inner zona fasciculata appears normal in young and old mice

• cells in the zona granulosa dedifferentiated with Nr5a1 deletion

Allelic Composition	Cyp11b2^{tm1.1(cre)Brlt}/Cyp11b2⁺ Nr0b1^tm1Lja/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp11b2^{tm1.1(cre)Brlt} mutation (0 available); any Cyp11b2 mutation (40 available)
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Nr0b1^tm1Lja mutation (2 available); any Nr0b1 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:204614 )

N	• loss of Nr0b1 does not impact ability of zona glomerusa cells to contribute to the inner zona fasciculata even at 8 months of age; postnatal zonation and lineage conversion in the adrenal gland are normal

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