All Phenotypes Spo11<tm1.1Gvpc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Spo11^tm1.1Gvpc
targeted mutation 1.1, Galina Petukhova
MGI:5538688

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc	involves: C57BL/6	MGI:5538719
ht2	Spo11^tm1.1Gvpc/Spo11^tm3Rdco	involves: C57BL/6	MGI:5538721
cx3	Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc	involves: 129S6/SvEvTac * C57BL/6	MGI:5538720

Allelic Composition	Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spo11^tm1.1Gvpc mutation (0 available); any Spo11 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Absence of germ cells beyond the spermatocyte stage and small ovaries with diminished number of follicles in Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc mice and absence of ovarian follicles in Spo11^tm1.1Gvpc/Spo11^tm3Rdco mice

reproductive system

absent mature ovarian follicles ( J:202231 )

small ovary ( J:202231 )

• more so than in Spo11^tm3.1Rdco homozygotes

abnormal uterus development ( J:202231 )

• underdeveloped

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes; more so in oocytes than spermatocytes

cellular

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes; more so in oocytes than spermatocytes

endocrine/exocrine glands

absent mature ovarian follicles ( J:202231 )

small ovary ( J:202231 )

• more so than in Spo11^tm3.1Rdco homozygotes

Allelic Composition	Spo11^tm1.1Gvpc/Spo11^tm3Rdco
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spo11^tm1.1Gvpc mutation (0 available); any Spo11 mutation (20 available)
Spo11^tm3Rdco mutation (0 available); any Spo11 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

early reproductive senescence ( J:202231 )

• while young female mice produce progeny, no viable litters are obtained in mice older than 6 months

reproductive system

azoospermia ( J:202231 )

• no germ cells beyond the spermatocyte stage

abnormal X-Y chromosome synapsis during male meiosis ( J:202231 )

arrest of male meiosis ( J:202231 )

• with a failure of complete synapsis

decreased mature ovarian follicle number ( J:202231 )

small ovary ( J:202231 )

small testis ( J:202231 )

early reproductive senescence ( J:202231 )

• while young female mice produce progeny, no viable litters are obtained in mice older than 6 months

male infertility ( J:202231 )

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes

• deficiency of double strand breaks at the chromosomal ends

cellular

azoospermia ( J:202231 )

• no germ cells beyond the spermatocyte stage

abnormal X-Y chromosome synapsis during male meiosis ( J:202231 )

arrest of male meiosis ( J:202231 )

• with a failure of complete synapsis

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes

• deficiency of double strand breaks at the chromosomal ends

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:202231 )

small ovary ( J:202231 )

small testis ( J:202231 )

Allelic Composition	Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmc3ip^tm1Rdco mutation (0 available); any Psmc3ip mutation (7 available)
Spo11^tm1.1Gvpc mutation (0 available); any Spo11 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

The number of meiotic double stranded breaks is reduced in Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc and Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco females

cellular

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes; more so in oocytes than spermatocytes

• deficiency of double strand breaks at the chromosomal ends

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes; more so in oocytes than spermatocytes

• deficiency of double strand breaks at the chromosomal ends

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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