Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm1.1Moon mutation
(0 available);
any
Tbx3 mutation
(49 available)
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mortality/aging
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• most mice die before E10.5
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cardiovascular system
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• authors state that mice exhibit cardiac morphology similar to that observed in Tbx3tm1Jcib homozygotes
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Allelic
Composition |
Tbx3tm1.1Moon/Tbx3+
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Genetic
Background |
involves: 129 * C57BL/6 * SJL |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm1.1Moon mutation
(0 available);
any
Tbx3 mutation
(49 available)
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reproductive system
cardiovascular system
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• atrial arrhythmia in embryos
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm1.1Moon mutation
(0 available);
any
Tbx3 mutation
(49 available)
Tbx3tm2Moon mutation
(0 available);
any
Tbx3 mutation
(49 available)
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Limb abnormalities and edema in Tbx3tm2Moon/Tbx3tm1.1Moon hypomorphs
mortality/aging
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• most mice die between E13.5 and E15.5
• no mice survive to birth
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• most mice die between E13.5 and E15.5
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cardiovascular system
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• cardiac conduction system hypoplasia without a change in cell proliferation or apoptosis
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• rare ventricular-arterial mal-alignment
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• large interventricular foramina in most mice at E13.5 to E14.5
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• atrial arrhythmia at E11.5 to E14.5
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• first detected at E11.5 and in most mice at E12.5
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limbs/digits/tail
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• authors state that mice exhibit limb abnormalities similar to Tbx3tm1Pa homozygotes
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embryo
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N |
• mice exhibit normal yolk sacs and placenta
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muscle
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• cardiac conduction system hypoplasia without a change in cell proliferation or apoptosis
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Analysis Tools
