Analysis Tools
hematopoietic system
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• mild at 6 weeks due to an increase in erythroblasts and myeloid cells
• severe at 12 weeks due to an increase in erythroblasts and myeloid cells
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• 3-fold at 6 weeks
• 8-fold at 12 weeks
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• increased CFU-GM in the bone marrow, but not spleen
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• in the spleen
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• in the liver
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• increased BFU-E in the spleen and bone marrow
• however, CFU-E numbers are normal in the bone marrow and spleen
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• mature erythroblasts
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• slightly at 2 weeks
• however, aged mice exhibit a drop in erythrocyte cell number to normal levels
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• at 2 to 3 months and plateau for 5 months
• however, aged mice exhibit a drop in hematocrit to normal levels
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• at 2 months and plateau for 4 months
• however, aged mice exhibit a drop in hemoglobin to normal levels
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microcytosis
(
J:202234
)
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• severe
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• severe, plateau for 6 months before decreasing in aged mice
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• early and more so in aged mice
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• at 3 months, mice exhibit increased LSK (2.3 times) and SLAM (2 time) cells in the bone marrow compared with control mice
• at 3 months, mice exhibit increased Lin- (1.5-fold), LSK (1.7-fold) and SLAM (3.7-fold) cells in the spleen compared with control mice
• 1, 3 and 6 month old mice exhibit a 3-, 4- and 5-fold increase, respectively, in total Lin- cells (bone marrow and spleen) compared with control mice
• at 3 months, mice exhibit a 3-fold and 7-fold increase in LSK and SLAM cells, respectively, compared with wild-type mice
• at 6 months, mice exhibit a 4-fold and 6-fold increase in LSK and SLAM cells, respectively, compared with wild-type mice
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• in aged mice
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• in transplantation experiments, bone marrow cells promotes hematopoietic cell proliferation compared to control cells
• however, IFNalpha treatment suppresses increased cell proliferation
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skeleton
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• in aged mice
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immune system
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• mild at 6 weeks due to an increase in erythroblasts and myeloid cells
• severe at 12 weeks due to an increase in erythroblasts and myeloid cells
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• 3-fold at 6 weeks
• 8-fold at 12 weeks
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• increased CFU-GM in the bone marrow, but not spleen
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• in the spleen
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• early and more so in aged mice
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• in aged mice
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growth/size/body
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• mild at 6 weeks due to an increase in erythroblasts and myeloid cells
• severe at 12 weeks due to an increase in erythroblasts and myeloid cells
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• 3-fold at 6 weeks
• 8-fold at 12 weeks
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